2-甲基-4-羰基-2-环己烯-1-羧酸乙酯合成路线 （共 41 条）
反应条件
(i) KOtBu, (ii) KOH; Multistep reaction;
参考文献
Nasipuri,D. et al.
Journal of the Indian Chemical Society, 1966 , vol. 43, p. 383 - 390
反应条件
sodium hydride in dimethyl sulfoxide
3 h; Ambient temperature;
参考文献
Baker, Murray V.; Ghitgas, Christine; Haynes, Richard K.; Hilliker, Audrey E.
Tetrahedron Letters, 1984 , vol. 25, # 15 p. 1625 - 1628
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Baker, Murray V.; Ghitgas, Christine; Haynes, Richard K.; Hilliker, Audrey E.; Lynch, Gregory J.; et al.
Australian Journal of Chemistry, 1984 , vol. 37, # 10 p. 2037 - 2058
反应条件
tetrafluoroboric acid in ethanol
3 h;
参考文献
Bezborodov, V. S.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, # 6 p. 1148 - 1152
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 6 p. 1268 - 1273
反应条件
1: 1.) NaH / 1.) DMF, reflux, 12 h, 2.) DMF, reflux, 12 h
2: KOH / ethanol / 20 h / Heating
3: 93.9 percent / LiAlH4 / diethyl ether
4: 97.7 percent / pyridine / 72 h / Ambient temperature
View Scheme
参考文献
Ladika, Mladen; Sunko, Dionis E.
Journal of Organic Chemistry, 1985 , vol. 50, # 23 p. 4544 - 4548
反应条件
(S)-(+)-1-(2-pyrrolidinylmethyl)-pyrrolidine in dimethyl sulfoxide
T=25°C; 1 h;
参考文献
Ramachary, Dhevalapally B.; Ramakumar, Kinthada; Narayana, Vidadala V.
Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1458 - 1463
反应条件
4 A molecular sieve in ethanol
T=25°C;
参考文献
Ramachary, Dhevalapally B.; Ramakumar, Kinthada; Narayana, Vidadala V.
Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1458 - 1463
反应条件
in methanol
T=25°C; 1 h;
参考文献
Ramachary, Dhevalapally B.; Ramakumar, Kinthada; Narayana, Vidadala V.
Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1458 - 1463
反应条件
hydrogen bromide; oxygen; copper(ll) bromide in 1,4-dioxane; water
T=20°C; 20 h; Sealed tube;
参考文献
Kikushima, Kotaro; Nishina, Yuta
RSC Advances, 2013 , vol. 3, # 43 p. 20150 - 20156
反应条件
iodine; sodium ethanolate in ethanol
Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Hegde, Shridhar G.; Kassim, Amude M.; Ingrum, April I.
Tetrahedron Letters, 1995 , vol. 36, # 46 p. 8395 - 8398
反应条件
potassium tert-butylate; tert-butyl alcohol
参考文献
Smith; Rouault
Journal of the American Chemical Society, 1943 , vol. 65, p. 631,634
