1.1: Inert atmosphere 2.1: triethylamine / Inert atmosphere 3.1: pyridinium chlorochromate / Inert atmosphere 4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 4.2: 1.5 h / -78 - 0 °C / Inert atmosphere 5.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 3.33 h / 20 °C / Inert atmosphere 6.1: diethyl ether / 0.25 h / 0 °C / Inert atmosphere 7.1: toluene / 6 h / Inert atmosphere; Reflux 8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere 9.1: lithium hydroxide hydrate / tetrahydrofuran / 1.5 h / Inert atmosphere 10.1: pyridine / toluene / 2.5 h / Inert atmosphere; Reflux 11.1: diethyl ether / 0.33 h / 0 °C / Inert atmosphere 12.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 4 h / 20 °C / Inert atmosphere 13.1: Cu(I)CN / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 13.2: 0.75 h / -78 °C / Inert atmosphere 14.1: dimethylsulfide; oxygen; ozone / methanol; dichloromethane / 2 h / -116 - 20 °C / Inert atmosphere 15.1: diethyl ether / 0 °C / Inert atmosphere 16.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere 16.2: 1.5 h / -78 - 0 °C / Inert atmosphere 17.1: triethylsilane; tetrakis(triphenylphosphine) palladium(0); lithium chloride / N,N-dimethyl-formamide / 2 h / 55 °C / Inert atmosphere 18.1: lithium hydroxide hydrate / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere 19.1: trifluoroacetic acid / tetrahydrofuran; dichloromethane / 10 h / Inert atmosphere View Scheme

1.1: triethylamine / Inert atmosphere 2.1: pyridinium chlorochromate / Inert atmosphere 3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 3.2: 1.5 h / -78 - 0 °C / Inert atmosphere 4.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 3.33 h / 20 °C / Inert atmosphere 5.1: diethyl ether / 0.25 h / 0 °C / Inert atmosphere 6.1: toluene / 6 h / Inert atmosphere; Reflux 7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere 8.1: lithium hydroxide hydrate / tetrahydrofuran / 1.5 h / Inert atmosphere 9.1: pyridine / toluene / 2.5 h / Inert atmosphere; Reflux 10.1: diethyl ether / 0.33 h / 0 °C / Inert atmosphere 11.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 4 h / 20 °C / Inert atmosphere 12.1: Cu(I)CN / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 12.2: 0.75 h / -78 °C / Inert atmosphere 13.1: dimethylsulfide; oxygen; ozone / methanol; dichloromethane / 2 h / -116 - 20 °C / Inert atmosphere 14.1: diethyl ether / 0 °C / Inert atmosphere 15.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere 15.2: 1.5 h / -78 - 0 °C / Inert atmosphere 16.1: triethylsilane; tetrakis(triphenylphosphine) palladium(0); lithium chloride / N,N-dimethyl-formamide / 2 h / 55 °C / Inert atmosphere 17.1: lithium hydroxide hydrate / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere 18.1: trifluoroacetic acid / tetrahydrofuran; dichloromethane / 10 h / Inert atmosphere View Scheme

1.1: pyridinium chlorochromate / Inert atmosphere 2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 2.2: 1.5 h / -78 - 0 °C / Inert atmosphere 3.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 3.33 h / 20 °C / Inert atmosphere 4.1: diethyl ether / 0.25 h / 0 °C / Inert atmosphere 5.1: toluene / 6 h / Inert atmosphere; Reflux 6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere 7.1: lithium hydroxide hydrate / tetrahydrofuran / 1.5 h / Inert atmosphere 8.1: pyridine / toluene / 2.5 h / Inert atmosphere; Reflux 9.1: diethyl ether / 0.33 h / 0 °C / Inert atmosphere 10.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 4 h / 20 °C / Inert atmosphere 11.1: Cu(I)CN / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 11.2: 0.75 h / -78 °C / Inert atmosphere 12.1: dimethylsulfide; oxygen; ozone / methanol; dichloromethane / 2 h / -116 - 20 °C / Inert atmosphere 13.1: diethyl ether / 0 °C / Inert atmosphere 14.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere 14.2: 1.5 h / -78 - 0 °C / Inert atmosphere 15.1: triethylsilane; tetrakis(triphenylphosphine) palladium(0); lithium chloride / N,N-dimethyl-formamide / 2 h / 55 °C / Inert atmosphere 16.1: lithium hydroxide hydrate / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere 17.1: trifluoroacetic acid / tetrahydrofuran; dichloromethane / 10 h / Inert atmosphere View Scheme

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 1.2: 1.5 h / -78 - 0 °C / Inert atmosphere 2.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 3.33 h / 20 °C / Inert atmosphere 3.1: diethyl ether / 0.25 h / 0 °C / Inert atmosphere 4.1: toluene / 6 h / Inert atmosphere; Reflux 5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere 6.1: lithium hydroxide hydrate / tetrahydrofuran / 1.5 h / Inert atmosphere 7.1: pyridine / toluene / 2.5 h / Inert atmosphere; Reflux 8.1: diethyl ether / 0.33 h / 0 °C / Inert atmosphere 9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 4 h / 20 °C / Inert atmosphere 10.1: Cu(I)CN / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 10.2: 0.75 h / -78 °C / Inert atmosphere 11.1: dimethylsulfide; oxygen; ozone / methanol; dichloromethane / 2 h / -116 - 20 °C / Inert atmosphere 12.1: diethyl ether / 0 °C / Inert atmosphere 13.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere 13.2: 1.5 h / -78 - 0 °C / Inert atmosphere 14.1: triethylsilane; tetrakis(triphenylphosphine) palladium(0); lithium chloride / N,N-dimethyl-formamide / 2 h / 55 °C / Inert atmosphere 15.1: lithium hydroxide hydrate / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere 16.1: trifluoroacetic acid / tetrahydrofuran; dichloromethane / 10 h / Inert atmosphere View Scheme

1.1: thionyl chloride / Inert atmosphere 2.1: Inert atmosphere 3.1: triethylamine / Inert atmosphere 4.1: pyridinium chlorochromate / Inert atmosphere 5.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 5.2: 1.5 h / -78 - 0 °C / Inert atmosphere 6.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 3.33 h / 20 °C / Inert atmosphere 7.1: diethyl ether / 0.25 h / 0 °C / Inert atmosphere 8.1: toluene / 6 h / Inert atmosphere; Reflux 9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere 10.1: lithium hydroxide hydrate / tetrahydrofuran / 1.5 h / Inert atmosphere 11.1: pyridine / toluene / 2.5 h / Inert atmosphere; Reflux 12.1: diethyl ether / 0.33 h / 0 °C / Inert atmosphere 13.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 4 h / 20 °C / Inert atmosphere 14.1: Cu(I)CN / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 14.2: 0.75 h / -78 °C / Inert atmosphere 15.1: dimethylsulfide; oxygen; ozone / methanol; dichloromethane / 2 h / -116 - 20 °C / Inert atmosphere 16.1: diethyl ether / 0 °C / Inert atmosphere 17.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere 17.2: 1.5 h / -78 - 0 °C / Inert atmosphere 18.1: triethylsilane; tetrakis(triphenylphosphine) palladium(0); lithium chloride / N,N-dimethyl-formamide / 2 h / 55 °C / Inert atmosphere 19.1: lithium hydroxide hydrate / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere 20.1: trifluoroacetic acid / tetrahydrofuran; dichloromethane / 10 h / Inert atmosphere View Scheme

1.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 3.33 h / 20 °C / Inert atmosphere 2.1: diethyl ether / 0.25 h / 0 °C / Inert atmosphere 3.1: toluene / 6 h / Inert atmosphere; Reflux 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere 5.1: lithium hydroxide hydrate / tetrahydrofuran / 1.5 h / Inert atmosphere 6.1: pyridine / toluene / 2.5 h / Inert atmosphere; Reflux 7.1: diethyl ether / 0.33 h / 0 °C / Inert atmosphere 8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 4 h / 20 °C / Inert atmosphere 9.1: Cu(I)CN / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 9.2: 0.75 h / -78 °C / Inert atmosphere 10.1: dimethylsulfide; oxygen; ozone / methanol; dichloromethane / 2 h / -116 - 20 °C / Inert atmosphere 11.1: diethyl ether / 0 °C / Inert atmosphere 12.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere 12.2: 1.5 h / -78 - 0 °C / Inert atmosphere 13.1: triethylsilane; tetrakis(triphenylphosphine) palladium(0); lithium chloride / N,N-dimethyl-formamide / 2 h / 55 °C / Inert atmosphere 14.1: lithium hydroxide hydrate / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere 15.1: trifluoroacetic acid / tetrahydrofuran; dichloromethane / 10 h / Inert atmosphere View Scheme

water T=190°C;

1: 88 percent / K2CO3; NaI / acetonitrile / 3 h / Heating 2: 29 mg 3: Jones' reagent / acetone / 2 h / 0 °C 4: 14.8 mg / diethyl ether; methanol / 0.25 h / 0 °C 5: 80 percent / LiHMDS / tetrahydrofuran / 1 h / 0 °C 6: 70 percent / aq. NaOH / methanol / 2 h / Heating View Scheme

1: DIBAL / toluene / 0.5 h / -78 °C 2: 372 mg / TsCl; DMAP / CH2Cl2 3: 88 percent / K2CO3; NaI / acetonitrile / 3 h / Heating 4: 29 mg 5: Jones' reagent / acetone / 2 h / 0 °C 6: 14.8 mg / diethyl ether; methanol / 0.25 h / 0 °C 7: 80 percent / LiHMDS / tetrahydrofuran / 1 h / 0 °C 8: 70 percent / aq. NaOH / methanol / 2 h / Heating View Scheme

1: 80 percent / LiHMDS / tetrahydrofuran / 1 h / 0 °C 2: 70 percent / aq. NaOH / methanol / 2 h / Heating View Scheme