反应条件
1: LiHMDS, Et2OBF3 2: TFA / CH2Cl2 3: DMAP 4: 2,6-lutidine 5: 66 percent / 1.) DIBAL-H; 2.) Et3SiH, Et2O*BF3 6: 1.) LiHMDS; 2.) PhSeCl / 1.) THF, 0 deg C; 2.) r.t. 7: 65 percent / NaH / tetrahydrofuran 8: KHMDS / tetrahydrofuran / 0 - 20 °C 9: hydrogen peroxide / tetrahydrofuran / 0 °C 10: 78 percent / hydrogen / PtO2 / ethanol / 360 h / 4137.2 Torr 11: 67 percent / aq. NaCl / dimethylsulfoxide / 2 h / 170 °C 12: TFA 13: Et3N 14: 50 percent / EtO2*BF3 / CH2Cl2 / Ambient temperature 15: 95 percent / sodium methoxide / 4 h / Ambient temperature 16: LiHMDS / tetrahydrofuran / 0 °C 17: 85 percent / 1.) 1N NaOH; 2.) HCl; 3.) Dowex50xB View Scheme
参考文献
Rubio, Almudena; Ezquerra, Jesus; Escribano, Ana; Remuinan, Modesto Jesus; Vaquero, Juan Jose
Tetrahedron Letters, 1998 , vol. 39, # 15 p. 2171 - 2174
