5-9氨基甲基)-4-(羧甲基)-1H-吡咯-3-丙酸合成路线 （共 29 条）
反应条件
1: 91.5 percent / NaOH, tetrabutylammonium hydrogen sulfate / CH2Cl2 / 2 h / 0 °C 2: hydrogen / PtO2 / 6 h / Ambient temperature 3: potassium hydroxide / aq. acetic acid / 4 h / 0 °C View Scheme
参考文献
Demopoulos, Basil J.; Anderson, Hugh J.; Loader, Charles E.; Faber, Kurt
Canadian Journal of Chemistry, 1983 , vol. 61, p. 2415 - 2422
反应条件
1: hydrogen / PtO2 / 6 h / Ambient temperature 2: potassium hydroxide / aq. acetic acid / 4 h / 0 °C View Scheme
参考文献
Demopoulos, Basil J.; Anderson, Hugh J.; Loader, Charles E.; Faber, Kurt
Canadian Journal of Chemistry, 1983 , vol. 61, p. 2415 - 2422
反应条件
hydrogenchloride Aufbewahren im Vakuum bei 18grad;
参考文献
Franck, Burchard; Stratmann, Helmut
Heterocycles, 1981 , vol. 15, # 2 p. 919 - 923
反应条件
1.1: platinum(IV) oxide; hydrogen; palladium / ethanol / 48 h / 2625.26 Torr 2.1: potassium hydroxide / water / 96 h / 20 °C / Darkness 2.2: 3 h / 0 °C / pH 6 - 7 View Scheme
参考文献
Dawadi, Prativa B. S.; Schulten, Els A. M.; Lugtenburg, Johan
Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 9 p. 341 - 349
反应条件
1.1: Jone's reagent / isopropyl alcohol; acetone / 2 h / 20 °C 2.1: diethyl ether; ethyl acetate / 2 h / 0 °C 3.1: platinum(IV) oxide; hydrogen; palladium / ethanol / 48 h / 2625.26 Torr 4.1: potassium hydroxide / water / 96 h / 20 °C / Darkness 4.2: 3 h / 0 °C / pH 6 - 7 View Scheme
参考文献
Dawadi, Prativa B. S.; Schulten, Els A. M.; Lugtenburg, Johan
Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 9 p. 341 - 349
反应条件
1.1: pyridine / dichloromethane 2.1: N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 2 h / 0 - 20 °C 3.1: pyridinium p-toluenesulfonate / methanol / 96 h / 20 °C 4.1: Jone's reagent / isopropyl alcohol; acetone / 2 h / 20 °C 5.1: diethyl ether; ethyl acetate / 2 h / 0 °C 6.1: platinum(IV) oxide; hydrogen; palladium / ethanol / 48 h / 2625.26 Torr 7.1: potassium hydroxide / water / 96 h / 20 °C / Darkness 7.2: 3 h / 0 °C / pH 6 - 7 View Scheme
参考文献
Dawadi, Prativa B. S.; Schulten, Els A. M.; Lugtenburg, Johan
Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 9 p. 341 - 349
反应条件
1.1: pyridinium p-toluenesulfonate / methanol / 96 h / 20 °C 2.1: Jone's reagent / isopropyl alcohol; acetone / 2 h / 20 °C 3.1: diethyl ether; ethyl acetate / 2 h / 0 °C 4.1: platinum(IV) oxide; hydrogen; palladium / ethanol / 48 h / 2625.26 Torr 5.1: potassium hydroxide / water / 96 h / 20 °C / Darkness 5.2: 3 h / 0 °C / pH 6 - 7 View Scheme
参考文献
Dawadi, Prativa B. S.; Schulten, Els A. M.; Lugtenburg, Johan
Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 9 p. 341 - 349
反应条件
1.1: N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 2 h / 0 - 20 °C 2.1: pyridinium p-toluenesulfonate / methanol / 96 h / 20 °C 3.1: Jone's reagent / isopropyl alcohol; acetone / 2 h / 20 °C 4.1: diethyl ether; ethyl acetate / 2 h / 0 °C 5.1: platinum(IV) oxide; hydrogen; palladium / ethanol / 48 h / 2625.26 Torr 6.1: potassium hydroxide / water / 96 h / 20 °C / Darkness 6.2: 3 h / 0 °C / pH 6 - 7 View Scheme
参考文献
Dawadi, Prativa B. S.; Schulten, Els A. M.; Lugtenburg, Johan
Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 9 p. 341 - 349
反应条件
1: aqueous NaOH 2: palladium; aqueous NH3 / Hydrogenation 3: pyridine; aqueous NH3; acetic acid and acetic acid anhydride 4: H2O 5: aqueous NaOH View Scheme
参考文献
Jackson; MacDonald
Canadian Journal of Chemistry, 1957 , vol. 35, p. 715,721
参考文献
Jackson; MacDonald
Canadian Journal of Chemistry, 1957 , vol. 35, p. 715,721
