(2S)-n-boc-顺式-4-溴-l-脯氨酸叔丁酯合成路线 （共 5 条）
反应条件
CuSPh in tetrahydrofuran; pentane T=-18°C; Posner reaction; 16 h;
参考文献
Koskinen, Ari M. P.; Helaja, Juho; Kumpulainen, Esa T. T.; Koivisto, Jari; Mansikkamaeki, Heidi; Rissanen, Kari
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6447 - 6453
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=20°C; Mitsunobu bromination; 15 h;
参考文献
Koskinen, Ari M. P.; Helaja, Juho; Kumpulainen, Esa T. T.; Koivisto, Jari; Mansikkamaeki, Heidi; Rissanen, Kari
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6447 - 6453
反应条件
1: 88 percent / Na2CO3 / H2O; dioxane
2: 80 percent / tetrahydrofuran / 20 - 60 °C
3: 74 percent / tetrabromomethane; triphenylphosphine / CH2Cl2 / 15 h / 20 °C
View Scheme
参考文献
Koskinen, Ari M. P.; Helaja, Juho; Kumpulainen, Esa T. T.; Koivisto, Jari; Mansikkamaeki, Heidi; Rissanen, Kari
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6447 - 6453
反应条件
1: 80 percent / tetrahydrofuran / 20 - 60 °C
2: 74 percent / tetrabromomethane; triphenylphosphine / CH2Cl2 / 15 h / 20 °C
View Scheme
参考文献
Koskinen, Ari M. P.; Helaja, Juho; Kumpulainen, Esa T. T.; Koivisto, Jari; Mansikkamaeki, Heidi; Rissanen, Kari
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6447 - 6453
反应条件
1: 88 percent / Na2CO3 / H2O; dioxane
2: 80 percent / tetrahydrofuran / 20 - 60 °C
3: 74 percent / tetrabromomethane; triphenylphosphine / CH2Cl2 / 15 h / 20 °C
View Scheme
参考文献
Koskinen, Ari M. P.; Helaja, Juho; Kumpulainen, Esa T. T.; Koivisto, Jari; Mansikkamaeki, Heidi; Rissanen, Kari
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6447 - 6453
