2,2’-二甲氧基联苯合成路线 （共 133 条）
反应条件
1: AlCl3, aluminium chloride / 1,2-dichloro-ethane / 20 °C
2: zinc; hydrogenchloride / |Reflux
3: thiourea; AlCl3, aluminium chloride / 1,2-dichloro-ethane / 50 °C
View Scheme
参考文献
COLGATE-PALMOLIVE COMPANY; NAIK, Ramesh; WALIKAR, Sanju; JEYARAMAN, Govindarajalu; RAMASWAMY RANGANATHAN, Koottungalmadhom
Patent: WO2013/95364 A1, 2013 ;
反应条件
1: bromine
2: tetrahydrofuran
View Scheme
参考文献
COLGATE-PALMOLIVE COMPANY; NAIK, Ramesh; WALIKAR, Sanju; JAYARAMAIAH, Ramesh; DEVAKI DEVI, Vangumalla; JEYARAMAN, Govindarajalu; RAMASWAMY RANGANATHAN, Koottungalmadhom
Patent: WO2013/95361 A1, 2013 ;
反应条件
1: N-bromosuccinmide / N,N-dimethyl-formamide / 12 h / 20 °C
2: boron tribromide / dichloromethane; hexane / -78 - 0 °C
3: 2 h / 120 °C
4: tetrakis(triphenylphosphine) palladium(0); cesium fluoride / water / 8 h / 80 °C / |Inert atmosphere
5: water; methanol; sodium hydrogencarbonate / 1 h / |Reflux
View Scheme
参考文献
Rempel, Viktor; Fuchs, Alexander; Hinz, Sonja; Karcz, Tadeusz; Lehr, Matthias; Koetter, Uwe; Mueller, Christa E.
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 1 p. 41 - 45
