2,2’-二甲氧基联苯合成路线 （共 133 条）
反应条件
1: 1-iodo-2-methoxybenzene With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; copper(l) iodide; sodium t-butanolate in toluene 0.166667 h; 2: 2-(hydroxydimethylsilyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester in toluene T=50°C; 24 h;
参考文献
Denmark, Scott E.; Baird, John D.; Regens, Christopher S.
Journal of Organic Chemistry, 2008 , vol. 73, # 4 p. 1440 - 1455
反应条件
manganese; cobalt (II) bromide; triphenylphosphine; trifluoroacetic acid in pyridine; N,N-dimethyl-formamide T=50°C;
参考文献
Amatore, Muriel; Gosmini, Corinne
Angewandte Chemie - International Edition, 2008 , vol. 47, # 11 p. 2089 - 2092
反应条件
1: 2-Methoxyphenyl-dihydroxyborane With potassium phosphate; N,N-diisopropyl 2-dicyclohexylphosphino-5-(3'-nitrophenyl)benzamide; palladium diacetate in tetrahydrofuran T=23°C; Suzuki-Miyaura cross-coupling; 0.0166667 h; Inert atmosphere; 2: 2-chloro-anisole in tetrahydrofuran T=23°C; Suzuki-Miyaura cross-coupling; 36 h; Inert atmosphere;
参考文献
Dai, Wei-Min; Li, Yannian; Zhang, Ye; Yue, Congyong; Wu, Jinlong
Chemistry - A European Journal, 2008 , vol. 14, # 18 p. 5538 - 5554
反应条件
oxygen; lithium chloride; manganese (II) chloride in tetrahydrofuran T=-5 - 0°C; Inert atmosphere; chemoselective reaction;
参考文献
Cahiez, Gerard; Duplais, Christophe; Buendia, Julien
Angewandte Chemie, International Edition, 2009 , vol. 48, # 36 p. 6731 - 6734
反应条件
indium; N-dodecane; lithium chloride; bis(η3-allyl-μ-chloropalladium(II)) in N,N-dimethyl-formamide T=100°C; 3 h;
参考文献
Taniguchi, Nobukazu
Journal of Organic Chemistry, 2004 , vol. 69, # 20 p. 6904 - 6906
反应条件
1: 1-n-heptyne With isopropylmagnesium chloride in tetrahydrofuran T=0 - 20°C; Inert atmosphere; 2: 2-methoxy-phenylmagnesium bromide With oxygen; lithium chloride; manganese (II) chloride in tetrahydrofuran T=-5 - 0°C; Inert atmosphere;
参考文献
Cahiez, Gerard; Duplais, Christophe; Buendia, Julien
Angewandte Chemie, International Edition, 2009 , vol. 48, # 36 p. 6731 - 6734
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in methanol Suzuki-type coupling; 16 h; Heating;
参考文献
Rodriguez, Nuria; Cuenca, Ana; Ramirez De Arellano, Carmen; Medio-Simon, Mercedes; Peine, Denissa; Asensio, Gregorio
Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 8070 - 8076
反应条件
1: With gallium(III) chloride in diethyl ether Transmetallation; 2: in water; toluene T=25°C; Coupling reaction; 0.0833333 h; Further stages.;
参考文献
Nichols, Peter J.; Papadopoulos, Stavroula; Raston, Colin L.
Chemical Communications, 2000 , # 14 p. 1227 - 1228
反应条件
1: 2-MeOC6H4MgX With indium(III) chloride in tetrahydrofuran T=20°C; 1 h; 2: 6-acetoxy-1-cyclohexene-1-carbonitrile With triphenylphosphine; tris-(dibenzylideneacetone)dipalladium(0) in tetrahydrofuran Heating;
参考文献
Baker, Lucas; Minehan, Thomas
Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3957 - 3960
反应条件
potassium dihydrogenphosphate; tetrabutylammomium bromide; palladium diacetate in water; N,N-dimethyl-formamide T=100°C; Suzuki cross-coupling;
参考文献
Gonzalez, Raquel Rodriguez; Liguori, Lucia; Carrillo, Alberto Martinez; Bjorsvik, Hans-Rene
Journal of Organic Chemistry, 2005 , vol. 70, # 23 p. 9591 - 9594
