(-)-象牙(洪达木)酮宁合成路线 （共 78 条）
反应条件
1: 1.) saturated methanolic HCl, 2.) CH3I / 1.) 0 deg C, 2.) CH3CN, RT, 70 h 2: 75 percent / pyridinium dichromate / CH2Cl2 / 3 h / Ambient temperature View Scheme
参考文献
Takano, Seiichi; Yonaga, Masahiro; Morimoto, Masamichi; Ogasawara, Kunio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 305 - 310
反应条件
1: LiAlH4 / diethyl ether 2: CrO3, pyridine View Scheme
参考文献
Magnus, Philip; Brown, Peter
Journal of the Chemical Society, Chemical Communications, 1985 , # 4 p. 184 - 186
反应条件
1: tert-butyl nitrite, potassium tert-butoxide / toluene; methanol / 3 h / 40 °C 2: 85 percent / NaOH / H2O; ethane-1,2-diol / 3 h / 155 - 160 °C View Scheme
参考文献
Czibula, Laszlo; Nemes, Andras; Visky, Gyoergy; Farkas, Maria; Szombathelyi, Zsolt; et al.
Liebigs Annalen der Chemie, 1993 , # 3 p. 221 - 230
反应条件
1: 15 mg / 0.5percent HCl / 16 h / Ambient temperature 2: 75 percent / pyridinium dichromate / CH2Cl2 / 3 h / Ambient temperature View Scheme
参考文献
Takano, Seiichi; Yonaga, Masahiro; Morimoto, Masamichi; Ogasawara, Kunio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 305 - 310
反应条件
hydrogenchloride; bromine 1.) H2O; 2.) 100 deg C, 48 h, H2O; Yield given. Multistep reaction;
参考文献
Lewin, Guy; Poisson, Jacques
Bulletin de la Societe Chimique de France, 1984 , vol. 2, # 11-12 p. 435 - 437
反应条件
pyridine; chromium(VI) oxide
参考文献
Magnus, Philip; Brown, Peter
Journal of the Chemical Society, Chemical Communications, 1985 , # 4 p. 184 - 186
反应条件
hydrogenchloride T=80°C; 336 h; ln A, Ea, ΔS<*>; degradation of vinpocetine in aqueous solutions, degradation products equilibria in solutions, effect of various pH, temperature and ionic strength, buffer catalysis, metal ion catalysis, oxygen effect, mechanism; Product distributionRate constantThermodynamic data;
参考文献
Muhammad; Adams; Lee
Journal of Pharmaceutical Sciences, 1988 , vol. 77, # 2 p. 126 - 131
反应条件
metabolism in rat urine and bile; labelled with T in position 3;
参考文献
Vereczkey; Tamas; Czira; Szporny
Arzneimittel-Forschung/Drug Research, 1980 , vol. 30, # 11 p. 1861 - 1865
