3-氯-5-硝基-2-吡啶甲腈合成路线 （共 4 条）
反应条件
copper (I) cyanide in acetonitrile
T=20 - 80°C; 6 h;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2004/50637 A2, 2004 ;
Location in patent: Page 66-67 ;
WO 2004/050637 A2
反应条件
trifluoroacetic anhydride in dichloromethane
参考文献
Salvati, Mark E.; Balog, James Aaron; Pickering, Dacia A.; Giese, Soren; Fura, Aberra; Li, Wenying; Patel, Ramesh N.; Hanson, Ronald L.; Mitt, Toomas; Roberge, Jacques Y.; Corte, James R.; Spergel, Steven H.; Rampulla, Richard A.; Misra, Raj N.; Xiao, Hai-Yun
Patent: US2004/77605 A1, 2004 ;
US 20040077605 A1
反应条件
1: With tin(IV) chloride in ethyl acetate
T=20 - 70°C; 4.16667 h;
2: With sodium hydrogencarbonate in ethyl acetate
T=20°C; 24 h;
参考文献
Axys Pharmaceuticals, Inc.
Patent: US2003/114457 A1, 2003 ;
US 20030114457 A1
反应条件
Calcium chloride in ethanol
参考文献
Salvati, Mark E.; Balog, James Aaron; Pickering, Dacia A.; Giese, Soren; Fura, Aberra; Li, Wenying; Patel, Ramesh N.; Hanson, Ronald L.; Mitt, Toomas; Roberge, Jacques Y.; Corte, James R.; Spergel, Steven H.; Rampulla, Richard A.; Misra, Raj N.; Xiao, Hai-Yun
Patent: US2004/77605 A1, 2004 ;
US 20040077605 A1
