2-(3-甲酰基-4-((2-甲氧基乙氧基)甲氧基)-5-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)苯基)琥珀酸二甲酯合成路线 (共 10 条)
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in N,N-dimethyl-formamide
参考文献
Shrader, William D.; Kolesnikov, Aleksandr; Burgess-Henry, Jana; Rai, Roopa; Hendrix, John; Hu, Huiyong; Torkelson, Steve; Ton, Tony; Young, Wendy B.; Katz, Bradley A.; Yu, Christine; Tang, Jie; Cabuslay, Ronnel; Sanford, Ellen; Janc, James W.; Sprengeler, Paul A.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1596 - 1600
反应条件
1: Pd(OAc)2; (o-Tol)3P; TEA
2: H2 / Pd(OH)2/C / methanol / 2585.74 Torr
3: MgCl2; TEA / acetonitrile / 4 h / Heating
4: N-bromosuccinimide / dimethylformamide / 0 °C
5: TEA / CH2Cl2
6: 75 percent / PdCl2(dppf); KOAc / dimethylformamide
View Scheme
参考文献
Shrader, William D.; Kolesnikov, Aleksandr; Burgess-Henry, Jana; Rai, Roopa; Hendrix, John; Hu, Huiyong; Torkelson, Steve; Ton, Tony; Young, Wendy B.; Katz, Bradley A.; Yu, Christine; Tang, Jie; Cabuslay, Ronnel; Sanford, Ellen; Janc, James W.; Sprengeler, Paul A.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1596 - 1600
反应条件
1: Pd(OAc)2; (o-Tol)3P; TEA
2: H2 / Pd(OH)2/C / methanol / 2585.74 Torr
3: MgCl2; TEA / acetonitrile / 4 h / Heating
4: N-bromosuccinimide / dimethylformamide / 0 °C
5: TEA / CH2Cl2
6: 75 percent / PdCl2(dppf); KOAc / dimethylformamide
View Scheme
参考文献
Shrader, William D.; Kolesnikov, Aleksandr; Burgess-Henry, Jana; Rai, Roopa; Hendrix, John; Hu, Huiyong; Torkelson, Steve; Ton, Tony; Young, Wendy B.; Katz, Bradley A.; Yu, Christine; Tang, Jie; Cabuslay, Ronnel; Sanford, Ellen; Janc, James W.; Sprengeler, Paul A.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1596 - 1600
反应条件
1: N-bromosuccinimide / dimethylformamide
2: DIPEA / CH2Cl2
3: KOAc; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) / dioxane
View Scheme
参考文献
Young, Wendy B.; Mordenti, Joyce; Torkelson, Steven; Shrader, William D.; Kolesnikov, Aleksandr; Rai, Roopa; Liu, Liang; Hu, Huiyong; Leahy, Ellen M.; Green, Michael J.; Sprengeler, Paul A.; Katz, Bradley A.; Yu, Christine; Janc, James W.; Elrod, Kyle C.; Marzec, Ulla M.; Hanson, Stephen R.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 2037 - 2041
反应条件
1: DIPEA / CH2Cl2
2: KOAc; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) / dioxane
View Scheme
参考文献
Young, Wendy B.; Mordenti, Joyce; Torkelson, Steven; Shrader, William D.; Kolesnikov, Aleksandr; Rai, Roopa; Liu, Liang; Hu, Huiyong; Leahy, Ellen M.; Green, Michael J.; Sprengeler, Paul A.; Katz, Bradley A.; Yu, Christine; Janc, James W.; Elrod, Kyle C.; Marzec, Ulla M.; Hanson, Stephen R.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 2037 - 2041
反应条件
1: MgCl2; TEA / acetonitrile
2: N-bromosuccinimide / dimethylformamide
3: DIPEA / CH2Cl2
4: KOAc; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) / dioxane
View Scheme
参考文献
Young, Wendy B.; Mordenti, Joyce; Torkelson, Steven; Shrader, William D.; Kolesnikov, Aleksandr; Rai, Roopa; Liu, Liang; Hu, Huiyong; Leahy, Ellen M.; Green, Michael J.; Sprengeler, Paul A.; Katz, Bradley A.; Yu, Christine; Janc, James W.; Elrod, Kyle C.; Marzec, Ulla M.; Hanson, Stephen R.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 2037 - 2041
反应条件
1: PdCl2; NEt3 / acetonitrile
2: Pd(OH)2; H2 / methanol
3: HBr / Heating
4: SOCl2
5: MgCl2; TEA / acetonitrile
6: N-bromosuccinimide / dimethylformamide
7: DIPEA / CH2Cl2
8: KOAc; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) / dioxane
View Scheme
参考文献
Young, Wendy B.; Mordenti, Joyce; Torkelson, Steven; Shrader, William D.; Kolesnikov, Aleksandr; Rai, Roopa; Liu, Liang; Hu, Huiyong; Leahy, Ellen M.; Green, Michael J.; Sprengeler, Paul A.; Katz, Bradley A.; Yu, Christine; Janc, James W.; Elrod, Kyle C.; Marzec, Ulla M.; Hanson, Stephen R.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 2037 - 2041
反应条件
1: SOCl2
2: MgCl2; TEA / acetonitrile
3: N-bromosuccinimide / dimethylformamide
4: DIPEA / CH2Cl2
5: KOAc; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) / dioxane
View Scheme
参考文献
Young, Wendy B.; Mordenti, Joyce; Torkelson, Steven; Shrader, William D.; Kolesnikov, Aleksandr; Rai, Roopa; Liu, Liang; Hu, Huiyong; Leahy, Ellen M.; Green, Michael J.; Sprengeler, Paul A.; Katz, Bradley A.; Yu, Christine; Janc, James W.; Elrod, Kyle C.; Marzec, Ulla M.; Hanson, Stephen R.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 2037 - 2041
反应条件
1: HBr / Heating
2: SOCl2
3: MgCl2; TEA / acetonitrile
4: N-bromosuccinimide / dimethylformamide
5: DIPEA / CH2Cl2
6: KOAc; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) / dioxane
View Scheme
参考文献
Young, Wendy B.; Mordenti, Joyce; Torkelson, Steven; Shrader, William D.; Kolesnikov, Aleksandr; Rai, Roopa; Liu, Liang; Hu, Huiyong; Leahy, Ellen M.; Green, Michael J.; Sprengeler, Paul A.; Katz, Bradley A.; Yu, Christine; Janc, James W.; Elrod, Kyle C.; Marzec, Ulla M.; Hanson, Stephen R.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 2037 - 2041
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in toluene
Suzuki reaction;
参考文献
Young, Wendy B.; Mordenti, Joyce; Torkelson, Steven; Shrader, William D.; Kolesnikov, Aleksandr; Rai, Roopa; Liu, Liang; Hu, Huiyong; Leahy, Ellen M.; Green, Michael J.; Sprengeler, Paul A.; Katz, Bradley A.; Yu, Christine; Janc, James W.; Elrod, Kyle C.; Marzec, Ulla M.; Hanson, Stephen R.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 2037 - 2041