反应条件
1: potassium carbonate / methanol; water / 0.5 h / |Inert atmosphere; |Cooling with ice
2: potassium hydroxide; water / methanol / 80 °C / |Inert atmosphere; |Cooling with ice
3: 1,2-dichloro-benzene / 2 h / 160 °C / |Inert atmosphere
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参考文献
Kyorin Pharmaceutical Co., Ltd.; Kissei Pharmaceutical Co., Ltd.; SETO, Shigeki; UMEI, Kentaro; NISHIGAYA, Yosuke; TANIOKA, Asao; KONDO, Tatsuhiro; KONDO, Atsushi; TATANI, Kazuya; KAWAMURA, Naohiro
Patent: EP2669285 A1, 2013 ;