N-(苄氧羰基)苯丙氨酰苯丙氨酸甲酯合成路线 （共 3 条）
参考文献
Kanosue, Yoshifumi; Kojima, Satoshi; Hiraga, Yoshikazu; Ohkata, Katsuo
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 6 p. 1187 - 1193
反应条件
Tris buffer; triethylamine; α-chymotrypsin in acetonitrile T=30°C; Acylation; pH=7.8; 1 h;
参考文献
Miyazawa, Toshifumi; Ensatsu, Eiichi; Tanaka, Kayoko; Yanagihara, Ryoji; Yamada, Takashi
Chemistry Letters, 1999 , # 10 p. 1013 - 1014
反应条件
1: 45percent HBr/CH3COOH / 0.5 h
2: Et3N, hydroxybenzotriazole (HOBt) / dimethylformamide / 16 h
3: 87 percent / 4 N aq. NaOH / methanol / 1 h / 0 °C
4: 1.) Et3N, 2.) hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / 1.) DMF, 0.5 h, 2.) DMF, RT, 16 h
View Scheme
参考文献
Lipkowski, Andrzej W.; Majewski, Tadeusz; Drabarek, Stefania
Polish Journal of Chemistry, 1980 , vol. 54, # 9 p. 1707 - 1712
