4,9-二氢-3H-吡啶并(3,4-B)吲哚合成路线 （共 34 条）
反应条件
boron trifluoride diethyl etherate in tetrahydrofuran; diethyl ether T=-23°C; 3 h;
参考文献
Nakagawa, Masako; Kawate, Tomohiko; Yamazaki, Hitoshi; Hino, Thoru
Journal of the Chemical Society, Chemical Communications, 1990 , # 14 p. 991 - 992
反应条件
1: 1.) n-BuLi / 1.) hexane, THF, -23 deg C, 20 min, 2.) hexane, THF, -23 deg C 2: diethyl ether; tetrahydrofuran / 1.5 h / -42 °C View Scheme
参考文献
Kawate; Nakagawa; Yamazaki; Hirayama; Hino
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 2 p. 287 - 291
反应条件
in 1,2-dichloro-ethane 1.5 h; Inert atmosphereReflux;
参考文献
Granger, Brett A.; Wang, Zhiqian; Kaneda, Kyosuke; Fang, Zhenglai; Martin, Stephen F.
ACS Combinatorial Science, 2013 , vol. 15, # 7 p. 379 - 386
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in dimethyl sulfoxide T=125°C; 10 h;
参考文献
Trieu, Tien Ha; Dong, Jing; Zhang, Qiang; Zheng, Bo; Meng, Tian-Zhuo; Lu, Xia; Shi, Xiao-Xin
European Journal of Organic Chemistry, 2013 , # 16 p. 3271 - 3277
反应条件
in chloroform 8 h; Reflux;
参考文献
Tetrahedron, , vol. 67, # 31 p. 5564 - 5571
反应条件
in dichloromethane T=0°C; 0.5 h;
参考文献
Sadhu, Partha Sarathi; Kumar, Singam Naveen; Chandrasekharam, Malapaka; Pica-Mattoccia, Livia; Cioli, Donato; Rao, Vaidya Jayathirtha
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1103 - 1106
反应条件
trichlorophosphate in dichloromethane
T=0 - 20°C; 2 h; Inert atmosphere;
参考文献
Huan, Uozhen; Klin, Beata; Darras, Fouad H.; Heilmann, Joer; Decker, Michael
European Journal of Medicinal Chemistry, 2014 , vol. 81, p. 15 - 21
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide
T=45°C; 0.5 h;
参考文献
Nicolaou; Mathison, Casey J. N.; Montagnon, Tamsyn
Angewandte Chemie - International Edition, 2003 , vol. 42, # 34 p. 4077 - 4082
反应条件
tetrabutylammomium bromide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in acetonitrile
T=20°C; 2 h;
参考文献
Panarese, Joseph D.; Waters, Stephen P.
Organic Letters, 2010 , vol. 12, # 18 p. 4086 - 4089
反应条件
hydrogenchloride in methanol; water
Rearrangement; 3 h; Heating;
参考文献
Somei; Noguchi; Yamagami; Kawada; Yamada
Heterocycles, 2000 , vol. 53, # 1 p. 7 - 10
