反应条件
1.1: sodium t-butanolate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere 1.2: 25 °C / Inert atmosphere 2.1: 5 Pd(II)/C(eggshell); hydrogen / ethanol / 2.5 h / 50 °C / 2068.65 Torr 3.1: AlCl3, aluminium chloride / n-heptane; dichloromethane / 0.75 h / -5 - 10 °C / Inert atmosphere 3.2: 0.5 h / -5 - 20 °C / Inert atmosphere 4.1: 5 Pd(II)/C(eggshell); hydrogen; triethylamine / tetrahydrofuran / 18 h / 20 °C / 2068.65 Torr 5.1: hydrogen bromide; acetic acid / water / 1.5 h / Inert atmosphere 6.1: water; acetonitrile / 6.25 h / 40 - 50 °C / Inert atmosphere 7.1: toluene / 70 °C / Inert atmosphere 8.1: acetic acid / toluene; acetonitrile / 21 h / 75 °C / Inert atmosphere 9.1: sodium hydroxide / tetrahydrofuran; methanol / 1.25 h / 50 °C / Inert atmosphere 9.2: 50 °C / Inert atmosphere View Scheme
参考文献
Yeh, Vince S. C.; Beno, David W. A.; Brodjian, Sevan; Brune, Michael E.; Cullen, Steven C.; Dayton, Brian D.; Dhaon, Madhup K.; Falls, Hugh D.; Gao, Ju; Grihalde, Nelson; Hajduk, Philip; Hansen, T. Matthew; Judd, Andrew S.; King, Andrew J.; Klix, Russel C.; Larson, Kelly J.; Lau, Yau Y.; Marsh, Kennan C.; Mittelstadt, Scott W.; Plata, Dan; Rozema, Michael J.; Segreti, Jason A.; Stoner, Eric J.; Voorbach, Martin J.; Wang, Xiaojun; Xin, Xili; Zhao, Gang; Collins, Christine A.; Cox, Bryan F.; Reilly, Regina M.; Kym, Philip R.; Souers, Andrew J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1751 - 1757
