1: With hydroxylamine hydrochloride; sodium hydroxide in ethanol; water
T=60°C; 22 h;
2: With hydrogenchloride in ethanol; water
T=20 - 80°C;
3: With sodium hydroxide in ethanol; water
参考文献
AMBIT BIOSCIENCE CORPORATION; APUY, Julius, L.; INSKI, Darren, E.; JAMES, Joyce, K.
Patent: WO2010/54058 A1, 2010 ;
Location in patent: Page/Page column 81 ;
WO 2010/054058 A1
