1-甲基-1,2,3,4-四氢喹啉合成路线 （共 86 条）
反应条件
formaldehyd in sodium hydroxide; acetic acid; acetonitrile
参考文献
Pfizer Inc.
Patent: US4738972 A1, 1988 ;
反应条件
diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate in dichloromethane T=20°C; 0.5 h;
参考文献
Babu, Thelagathoti Hari; Shanthi, Gnanamani; Perumal, Paramasivan T.
Tetrahedron Letters, 2009 , vol. 50, # 24 p. 2881 - 2884
反应条件
hydrogenchloride; tin
参考文献
Meisenheimer
Justus Liebigs Annalen der Chemie, 1911 , vol. 385, p. 138
反应条件
palladium 10 on activated carbon; zinc T=150°C; 40 h; Autoclave;
参考文献
Abarca, Belen; Adam, Rosa; Ballesteros, Rafael
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 9 p. 1826 - 1833
反应条件
triethylaluminum; pyridine; bis(acetylacetonate)nickel(II) in tetrahydrofuran; toluene T=80 - 100°C; 5 h;
参考文献
Canoira, Laureano; Rodriguez, J. Gonzalo
Journal of Chemical Research, Miniprint, 1988 , # 2 p. 646 - 666
反应条件
in methanol; dichloromethane
参考文献
The United States of America as represented by the United States Department of Energy
Patent: US4622400 A1, 1986 ;
反应条件
1: 63 percent / NaH / dimethylformamide / 1.5 h / 20 °C 2: 98 percent / BH3*MTHF / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Partali, Vassilia; Jolidon, Synese; Hansen, Hans-Juergen
Helvetica Chimica Acta, 1985 , vol. 68, p. 1952 - 1960
反应条件
formic acid; triethylamine T=150°C; 24 h; Inert atmosphereGreen chemistry;
参考文献
Jiang, Xue; Wang, Chao; Wei, Yawen; Xue, Dong; Liu, Zhaotie; Xiao, Jianliang
Chemistry - A European Journal, 2014 , vol. 20, # 1 p. 58 - 63
反应条件
1: H2 / Raney-Ni / 760 Torr 2: 86 percent / 9-borabicyclo<3.3.1>nonane / tetrahydrofuran / 1 h / 65 °C View Scheme
参考文献
Collins, Christopher J.; Lanz, Marc; Singaram, Bakthan
Tetrahedron Letters, 1999 , vol. 40, # 19 p. 3673 - 3676
反应条件
1: With tetra-(n-butyl)ammonium iodide; caesium carbonate in N,N-dimethyl-formamide T=60°C; 10 h; 2: With Merrifield's peptide resin in N,N-dimethyl-formamide T=60°C; 12 h; 3: With lithium aluminium tetrahydride in tetrahydrofuran 8 h; Heating;
参考文献
Salvatore, Ralph N; Chu, Feixia; Nagle, Advait S; Kapxhiu, Elona A; Cross, Richard M; Jung, Kyung Woon
Tetrahedron, 2002 , vol. 58, # 17 p. 3329 - 3347
