1-甲基-1,2,3,4-四氢喹啉合成路线 （共 86 条）
反应条件
1: 98 percent / NaIO4 / methanol / 6 h / 20 °C 2: 60 percent / TFAA; BF3*Et2O / benzene / 2 h / 20 °C 3: 98 percent / NaBH4; NiCl2*6H2O / methanol; tetrahydrofuran / 1.5 h / 20 °C 4: 80 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating View Scheme
参考文献
Toda, Jun; Sakagami, Michiya; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 9 p. 1269 - 1275
反应条件
1: 60 percent / TFAA; BF3*Et2O / benzene / 2 h / 20 °C 2: 98 percent / NaBH4; NiCl2*6H2O / methanol; tetrahydrofuran / 1.5 h / 20 °C 3: 80 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating View Scheme
参考文献
Toda, Jun; Sakagami, Michiya; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 9 p. 1269 - 1275
反应条件
1: 98 percent / NaBH4; NiCl2*6H2O / methanol; tetrahydrofuran / 1.5 h / 20 °C 2: 80 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating View Scheme
参考文献
Toda, Jun; Sakagami, Michiya; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 9 p. 1269 - 1275
反应条件
1: AgCl 2: Na(Hg) / aq. ethanol / 1.) r.t., 1 h; 2.) 95-100 deg C, 1.5 h View Scheme
参考文献
Partali, Vassilia; Jolidon, Synese; Hansen, Hans-Juergen
Helvetica Chimica Acta, 1985 , vol. 68, p. 1952 - 1960
反应条件
2: platinum; methanol / Hydrogenation View Scheme
参考文献
Uhle; Jacobs
Journal of Organic Chemistry, 1945 , vol. 10, p. 76,85
参考文献
Davies; Sarvige
Journal of the Chemical Society, 1950 , p. 890
反应条件
formic acid; triethylamine
参考文献
Judin et al.
Zhurnal Obshchei Khimii, 1957 , vol. 27, p. 3021,3024; engl. Ausg. S. 3051, 3053
Full Text Show Details
Kost; Judin
Zhurnal Obshchei Khimii, 1956 , vol. 26, p. 1720; engl. Ausg. S. 1929
反应条件
1-methyl-1,2,3,4-tetrahydroquinolinetricarbonylchromium; iodine in tetrahydrofuran T=-78°C; 22 h; Product distribution;
参考文献
Ohlsson, Bengt; Ullenius, Christina
Journal of Organometallic Chemistry, 1988 , vol. 350, p. 35 - 56
反应条件
1: 80 percent 2: 92 percent / LiAlH4 View Scheme
参考文献
Gawinecki, Ryszard; Kolehmainen, Erkki; Kauppinen, Reijo
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1998 , # 1 p. 25 - 30
反应条件
1: SOCl2 2: aqueous NaOH 3: LiAlH4 4: diethylamine; phenyl lithium; diethyl ether View Scheme
参考文献
Huisgen; Koenig
Chemische Berichte, 1959 , vol. 92, p. 203,211
