1-甲基-1,2,3,4-四氢喹啉合成路线 （共 86 条）
反应条件
1: 50 percent / acetonitrile / 8 h / Heating
2: 95 percent Chromat. / NaHCO3 / glycerol; H2O / 140 °C
View Scheme
参考文献
Katayama, Hajime; Takatsu, Noriyuki
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 9 p. 2465 - 2477
反应条件
chlorosulfonic acid in dichloromethane
T=0 - 20°C; 16 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION; DANCA, Mihaela, Diana; DUNN, Robert; TEHIM, Ashok; XIE, Wenge
Patent: WO2010/21797 A1, 2010 ;
Location in patent: Page/Page column 66 ;
WO 2010/021797 A1
反应条件
sulfuric acid in diethyl ether
T=5 - 170°C; 3 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION; DANCA, Mihaela, Diana; DUNN, Robert; TEHIM, Ashok; XIE, Wenge
Patent: WO2010/21797 A1, 2010 ;
Location in patent: Page/Page column 67 ;
WO 2010/021797 A1
参考文献
Bahner et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 4198
参考文献
Bahner et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 4198
参考文献
Yoshimitsu, Takehiko; Matsuda, Kenichi; Nagaoka, Hiroto; Tsukamoto, Koji; Tanaka, Tetsuaki
Organic Letters, 2007 , vol. 9, # 24 p. 5115 - 5118
