3-叔丁基-4-羟基苯甲腈合成路线 （共 5 条）
反应条件
hydroxylamine hydrochloride; acetic acid
1 h; Reflux;
参考文献
GLAXO GROUP LIMITED; ALVARO, Giuseppe; DECOR, Anne; FONTANA, Stefano; HAMPRECHT, Dieter; LARGE, Charles; MARASCO, Agostino
Patent: WO2011/69951 A1, 2011 ;
Location in patent: Page/Page column 82-83 ;
WO 2011/069951 A1
反应条件
1.1: sodium hydroxide; water / methanol / 4 h / 60 °C
1.2: 0 - 20 °C / pH 5 - 6
2.1: hydroxylamine hydrochloride; acetic acid / 1 h / Reflux
View Scheme
参考文献
GLAXO GROUP LIMITED; ALVARO, Giuseppe; DECOR, Anne; FONTANA, Stefano; HAMPRECHT, Dieter; LARGE, Charles; MARASCO, Agostino
Patent: WO2011/69951 A1, 2011 ;
WO 2011/069951 A1
反应条件
in N,N-dimethyl-formamide
5 h; Reflux;
参考文献
Nizovtsev, Alexey V.; Scheurer, Andreas; Kosog, Boris; Heinemann, Frank W.; Meyer, Karsten
European Journal of Inorganic Chemistry, 2013 , # 14 p. 2538 - 2548
反应条件
1: sulfuric acid / methanol / 5 - 25 °C
2: N,N-dimethyl-formamide / 5 h / |Reflux
View Scheme
参考文献
Nizovtsev, Alexey V.; Scheurer, Andreas; Kosog, Boris; Heinemann, Frank W.; Meyer, Karsten
European Journal of Inorganic Chemistry, 2013 , # 14 p. 2538 - 2548
反应条件
water; sodium hydroxide in ethanol
Inert atmosphereReflux;
参考文献
Song, Feijie; Wang, Cheng; Falkowski, Joseph M.; Ma, Liqing; Lin, Wenbin
Journal of the American Chemical Society, 2010 , vol. 132, # 43 p. 15390 - 15398
