4-(4-氨基苯基)-2-噻唑羧酸乙酯合成路线 (共 4 条)
反应条件
tin(ll) chloride in ethanol
Heating;
参考文献
Shearer, Barry G.; Chao, Esther Y.; Uehling, David E.; Deaton, David N.; Cowan, Conrad; Sherman, Bryan W.; Milliken, Tula; Faison, Walter; Brown, Kathleen; Adkison, Kimberly K.; Lee, Frank
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4670 - 4677
反应条件
1: With hydrogenchloride; SnCl2·2H2O in ethanol; water
2 h; Reflux;
2: With potassium hydroxide in ethanol; water
T=0°C;
参考文献
SELEXAGEN THERAPEUTICS, INC.; VERNIER, Jean-Michel; MAY, John; O'CONNOR, Patrick; RIPKA, William; PINKERTON, Anthony; BOUNAUD, Pierre-Yves; HOPKINS, Stephanie
Patent: WO2011/85128 A1, 2011 ;
Location in patent: Page/Page column 55 ;
反应条件
1: 88 percent / ethanol / Heating
2: 96 percent / SnCl2 / ethanol / Heating
View Scheme
参考文献
Shearer, Barry G.; Chao, Esther Y.; Uehling, David E.; Deaton, David N.; Cowan, Conrad; Sherman, Bryan W.; Milliken, Tula; Faison, Walter; Brown, Kathleen; Adkison, Kimberly K.; Lee, Frank
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4670 - 4677
反应条件
1.1: ethanol / 19 h / 80 °C
2.1: hydrogenchloride; SnCl2·2H2O / ethanol; water / 2 h / Reflux
2.2: 0 °C
View Scheme
参考文献
SELEXAGEN THERAPEUTICS, INC.; VERNIER, Jean-Michel; MAY, John; O'CONNOR, Patrick; RIPKA, William; PINKERTON, Anthony; BOUNAUD, Pierre-Yves; HOPKINS, Stephanie
Patent: WO2011/85128 A1, 2011 ;