5-溴-4-碘吡啶-3-羧酸合成路线 （共 2 条）
反应条件
1: With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran; hexane T=-50°C; 0.5 h; 2: With iodine in tetrahydrofuran; hexane T=-50°C; 2 h; 3: With hydrogenchloride in water pH=3;
参考文献
Lazaar, Jalal; Rebstock, Anne-Sophie; Mongin, Florence; Godard, Alain; Trecourt, Francois; Marsais, Francis; Queguiner, Guy
Tetrahedron, 2002 , vol. 58, # 33 p. 6723 - 6728
反应条件
1: With n-butyllithium; (tert-butyldimethylsilyl)-tert-butylamine in tetrahydrofuran; hexane
T=-50°C; 30 h;
2: With water in tetrahydrofuran; hexane
T=20°C; 0.5 h;
3: With hydrogenchloride in water
pH=3;
参考文献
Lazaar, Jalal; Rebstock, Anne-Sophie; Mongin, Florence; Godard, Alain; Trecourt, Francois; Marsais, Francis; Queguiner, Guy
Tetrahedron, 2002 , vol. 58, # 33 p. 6723 - 6728
