3-(4-氟苯基)-5-甲基异噁唑合成路线 （共 9 条）
反应条件
C46H48N6O5Pd; potassium acetate in N,N-dimethyl acetamide
T=160°C; 24 h; Inert atmosphere;
参考文献
Nandi, Debkumar; Jhou, Yang-Ming; Lee, Jhen-Yi; Kuo, Bing-Chiuan; Liu, Chien-Yu; Huang, Pei-Wen; Lee, Hon Man
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 9384 - 9390
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran; N,N-dimethyl-formamide
T=90°C; 10 h;
参考文献
Xu, Wei Ming; Tang; Huang, Xian
Tetrahedron, 2005 , vol. 61, # 2 p. 501 - 506
反应条件
1: propargyl bromide With iodine; magnesium; mercury dichloride in tetrahydrofuran; toluene
T=20°C; 2 h;
2: p-fluorobenzonitrile oxide in tetrahydrofuran; toluene
5 h;
参考文献
Sampath Kumar; Singh, Parvinder Pal; Shafi, Syed; Reddy, Pitta Bhaskar; Shravankumar, Kankala; Reddy, Doma Mahender
Tetrahedron Letters, 2007 , vol. 48, # 5 p. 887 - 890
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -40 °C
1.2: 63 percent / tetrahydrofuran; hexane / 2 h / -40 - 20 °C
2.1: 67 percent / conc. H2SO4 / 2 h / 80 °C
View Scheme
参考文献
Dileep Kumar; Ho, ManKit M.; Leung, Jennifer M.; Toyokuni, Tatsushi
Advanced Synthesis and Catalysis, 2002 , vol. 344, # 10 p. 1146 - 1151
反应条件
1.1: triethylamine / tetrahydrofuran / 0.17 h / 0 - 5 °C
2.1: indium / tetrahydrofuran; H2O; toluene / 3 h
2.2: tetrahydrofuran; H2O; toluene / 24 h
View Scheme
参考文献
Sampath Kumar; Singh, Parvinder Pal; Shafi, Syed; Reddy, Pitta Bhaskar; Shravankumar, Kankala; Reddy, Doma Mahender
Tetrahedron Letters, 2007 , vol. 48, # 5 p. 887 - 890
反应条件
1: CH3I; NaI / dimethylformamide / 20 h / 80 °C
2: DBU / tetrahydrofuran; dimethylformamide / 10 h / 90 °C
View Scheme
参考文献
Xu, Wei Ming; Tang; Huang, Xian
Tetrahedron, 2005 , vol. 61, # 2 p. 501 - 506
反应条件
1: 73 percent / triethylamine / CH2Cl2 / 6 h / 20 °C
2: CH3I; NaI / dimethylformamide / 20 h / 80 °C
3: DBU / tetrahydrofuran; dimethylformamide / 10 h / 90 °C
View Scheme
参考文献
Xu, Wei Ming; Tang; Huang, Xian
Tetrahedron, 2005 , vol. 61, # 2 p. 501 - 506
反应条件
1: NCS / 3 h / 20 °C
2: 73 percent / triethylamine / CH2Cl2 / 6 h / 20 °C
3: CH3I; NaI / dimethylformamide / 20 h / 80 °C
4: DBU / tetrahydrofuran; dimethylformamide / 10 h / 90 °C
View Scheme
参考文献
Xu, Wei Ming; Tang; Huang, Xian
Tetrahedron, 2005 , vol. 61, # 2 p. 501 - 506
反应条件
1: propargyl bromide With indium in tetrahydrofuran; water; toluene
3 h;
2: p-fluorobenzonitrile oxide in tetrahydrofuran; water; toluene
24 h;
参考文献
Sampath Kumar; Singh, Parvinder Pal; Shafi, Syed; Reddy, Pitta Bhaskar; Shravankumar, Kankala; Reddy, Doma Mahender
Tetrahedron Letters, 2007 , vol. 48, # 5 p. 887 - 890
