2-C-甲基-D-核糖酸-1,4-内酯合成路线 （共 25 条）
反应条件
1: With sodium methylate; copper dichloride in tetrahydrofuran; methanol T=20 - 40°C; 3 h; 2: in tetrahydrofuran; methanol T=23°C; 1 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; STEINHARDT, Sarah Evelyn; EASTGATE, Martin D.
Patent: WO2013/188480 A1, 2013 ;
Location in patent: Paragraph 0053 ;
参考文献
Naus, Petr; Perlikova, Pavla; Pohl, Radek; Hocek, Michal
Collection of Czechoslovak Chemical Communications, 2011 , vol. 76, # 8 p. 957 - 988
反应条件
trifluoroacetic acid in ethyl acetate 3 h;
参考文献
Lopez-Herrera, F. J.; Sarabia-Garcia, F.; Pino-Gonzalez, M. S.; Garcia-Aranda, J. F.
Journal of Carbohydrate Chemistry, 1994 , vol. 13, # 5 p. 767 - 776
反应条件
1: With dimethyl amine in water; acetic acid Large scale reaction; 2: With Ca(OH)2 in water
参考文献
Victoria Booth; Jenkinson, Sarah F.; Best, Daniel; Nieto, Fernando Fernandez; Estevez, Ramon J.; Wormald, Mark R.; Weymouth-Wilson, Alexander C.; Fleet, George W.J.
Tetrahedron Letters, 2009 , vol. 50, # 36 p. 5088 - 5093
反应条件
Ca(OH)2 in water T=20°C; 1704 h; Inert atmosphere;
参考文献
Pontiggia, Rodrigo; Pontiggia, Osvaldo; Simian, Marina; Montserrat, Javier M.; Engels, Joachim W.; Iribarren, Adolfo M.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 9 p. 2806 - 2808
反应条件
1: in water T=20°C; Kiliani reaction; 96 h; Reflux; 2: With Amberlite.(R). IR 120 (H+) in water optical yield given as percent dediastereoselective reaction;
参考文献
Booth, Kathrine V.; da Cruz, Filipa P.; Hotchkiss, David J.; Jenkinson, Sarah F.; Jones, Nigel A.; Weymouth-Wilson, Alexander C.; Clarkson, Robert; Heinz, Thomas; Fleet, George W.J.
Tetrahedron Asymmetry, 2008 , vol. 19, # 20 p. 2417 - 2424
反应条件
calcium hydroxide powder in water
参考文献
Hotchkiss, David J.; Jenkinson, Sarah F.; Storer, Richard; Heinz, Thomas; Fleet, George W.J.
Tetrahedron Letters, 2006 , vol. 47, # 3 p. 315 - 318
反应条件
1: ethanol; methanol; acetic acid / 1.5 h / 80 °C 2: Ca(OH)2 / H2O / 24 h / 70 °C View Scheme
参考文献
Hotchkiss, David J.; Jenkinson, Sarah F.; Storer, Richard; Heinz, Thomas; Fleet, George W.J.
Tetrahedron Letters, 2006 , vol. 47, # 3 p. 315 - 318
反应条件
1: With water; CaO 2: With sulfuric acid in water
参考文献
Booth, Kathrine V.; da Cruz, Filipa P.; Hotchkiss, David J.; Jenkinson, Sarah F.; Jones, Nigel A.; Weymouth-Wilson, Alexander C.; Clarkson, Robert; Heinz, Thomas; Fleet, George W.J.
Tetrahedron Asymmetry, 2008 , vol. 19, # 20 p. 2417 - 2424
参考文献
Hotchkiss, David J.; Jenkinson, Sarah F.; Storer, Richard; Heinz, Thomas; Fleet, George W.J.
Tetrahedron Letters, 2006 , vol. 47, # 3 p. 315 - 318
