1: With 2,2,2-trimethylacetic acid; (S)-(+)-1-tert-butyldiphenylsilyloxy-3-(3'-methyl-3'H-imidazol-4'-yl)-2-(2'',4'',6''-triisopropylbenzenesulfonylamino)propane in tetrachloromethane T=20°C; 2 h; Inert atmosphere; 2: With hydrogenchloride; water in tetrachloromethane Inert atmosphere; optical yield given as percent eeenantioselective reaction;
1: With 2,2,2-trimethylacetic acid; (S)-(+)-1-tert-butyldiphenylsilyloxy-3-(3'-methyl-3'H-imidazol-4'-yl)-2-(2'',4'',6''-triisopropylbenzenesulfonylamino)propane in tetrachloromethane T=-20°C; 24 h; Inert atmosphere; 2: With hydrogenchloride; water in tetrachloromethane Inert atmosphere;
lithium aluminium tetrahydride; titanium tetrachloride in tetrahydrofuran T=-5°C; 0.5 h; further reagents: TiCl3-LiAlH4;
参考文献
Garcia, Mariano; Campo, Carmen del; Llama, Emilio F.; Sinisterra, Jose V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 13 p. 1771 - 1774
