1: With hydrogenchloride; water in 1,4-dioxane 6 h; Reflux; 2: With pyridine; (L)-cysteine methyl ester hydrochloride T=60°C; 1 h; 3: With N-(trimethylsilyl)-imidazole T=60°C; 0.5 h;
1: 4-methyl-morpholine; HATU / acetonitrile / 4 h / 20 °C / Inert atmosphere 2: water; trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C 3: pH 7.4 / aq. phosphate buffer View Scheme
参考文献
Iddon, Lisa; Richards, Selena E.; Johnson, Caroline H.; Harding, John R.; Wilson, Ian D.; Nicholson, Jeremy K.; Lindon, John C.; Stachulski, Andrew V.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 3 p. 926 - 934
