3-甲氧基-2-硝基苯甲酸合成路线 （共 46 条）
反应条件
pyridine hydrochloride
参考文献
Cleaver,L. et al.
Australian Journal of Chemistry, 1976 , vol. 29, p. 2003 - 2021
反应条件
1: sulfuric acid; silver sulphate; iodine / 48 h / 20 °C / |Darkness; |Inert atmosphere 2: diethyl-sulphide; AlCl3, aluminium chloride / dichloromethane / 48 h / 40 °C / |Inert atmosphere View Scheme
参考文献
Jabri, Salman Y.; Overman, Larry E.
Journal of the American Chemical Society, 2013 , vol. 135, # 11 p. 4231 - 4234
反应条件
1: SOCl2 2: 1.) NaN3, 2.) H2O, 4.) NaOH, 5.) HCl 3: 1.) 98percent sulfuric acid, NaNO2, 2.) CuCl2, 36percent aq. HCl / 1.) acetic acid, 10 deg C, 1 h, 2.) acetic acid, RT, 1 h View Scheme
参考文献
Kimura; Watanabe; Matsui; Hayashi; Tanaka; Ohtsuka; Saeki; Kogushi; Kabayashi; Akasaka; Yamagishi; Saitou; Yamatsu
Journal of Medicinal Chemistry, 1993 , vol. 36, # 11 p. 1641 - 1653
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 1 h;
参考文献
Japan Tobacco Inc.
Patent: EP1564210 A1, 2005 ;
Location in patent: Page/Page column 64 ;
反应条件
sulfuric acid Reflux;
参考文献
Hansen, Finn K.; Khankischpur, Mehdi; Tolaymat, Ibrahim; Mesaros, Renata; Dannhardt, Gerd; Geffken, Detlef
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5031 - 5034
反应条件
phosphorus; hydrogen iodide
参考文献
Warnell
Biochemical Preparations, 1958 , vol. 6, p. 20,21
反应条件
1: SOCl2 2: 1.) NaN3, 2.) H2O, 4.) NaOH, 5.) HCl 3: 1.) NaNO2, HCl, 2.) NaSbF6, 3.) SiO2 View Scheme
参考文献
Kimura; Watanabe; Matsui; Hayashi; Tanaka; Ohtsuka; Saeki; Kogushi; Kabayashi; Akasaka; Yamagishi; Saitou; Yamatsu
Journal of Medicinal Chemistry, 1993 , vol. 36, # 11 p. 1641 - 1653
反应条件
sulfuric acid; bromine; silver sulphate T=20°C; 2 h;
参考文献
AMR Technology, Inc.
Patent: US2006/183769 A1, 2006 ;
Location in patent: Page/Page column 41-42 ;
反应条件
1: SOCl2 2: 1.) NaN3, 2.) H2O, 4.) NaOH, 5.) HCl 3: 1.) 98percent sulfuric acid, NaNO2, 2.) CuCl2, 36percent aq. HCl / 1.) acetic acid, 10 deg C, 1 h, 2.) acetic acid, RT, 1 h 4: H2 / 10percent Pd/C / ethyl acetate / 1 h / 760 Torr View Scheme
参考文献
Kimura; Watanabe; Matsui; Hayashi; Tanaka; Ohtsuka; Saeki; Kogushi; Kabayashi; Akasaka; Yamagishi; Saitou; Yamatsu
Journal of Medicinal Chemistry, 1993 , vol. 36, # 11 p. 1641 - 1653
反应条件
1: tin; hydrochloric acid 2: methanol / 100 °C / im Rohr 3: fuming hydriodic acid; red phosphorus / 100 °C View Scheme
参考文献
Ewins
Journal of the Chemical Society, 1912 , vol. 101, p. 548
