8-氯-3,7-二氢-1,3,7-三甲基-1H-嘌呤-2,6-二酮合成路线 （共 61 条）
参考文献
Long
Journal of the American Chemical Society, 1947 , vol. 69, p. 2939
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
Suzuki cross-coupling reaction; 96 h;
参考文献
Vollmann, Karl; Mueller, Christa E.
Heterocycles, 2002 , vol. 57, # 5 p. 871 - 879
反应条件
ethanol; ammonia
T=150 - 160°C; unter Druck;
参考文献
Gomberg
American Chemical Journal, 1900 , vol. 23, p. 64
反应条件
ethanol
T=150°C; unter Druck;
参考文献
Blicke; Godt
Journal of the American Chemical Society, 1954 , vol. 76, p. 2835
反应条件
potassium hydroxide
T=140°C;
参考文献
Yoshitomi
Yakugaku Zasshi, 1929 , vol. 49, p. 46
Chem. Zentralbl., 1929 , vol. 100, # I p. 2991
Full Text Show Details
Yoshitomi; Miyanaga; Nagae
Yakugaku Zasshi, 1926 , p. 5
Chem. Zentralbl., 1926 , vol. 97, # II p. 2726
反应条件
ethanol; water
T=100°C;
参考文献
Lueppo-Cramer
Chemische Berichte, 1894 , vol. 27, p. 3089
参考文献
Chakravarty; Jones
Journal of the American Pharmaceutical Association (1912-1977), 1958 , vol. 47, p. 233
反应条件
1: benzyl alcohol With sodium
2: 8-Chlorocaffeine T=170°C;
参考文献
Strydom, Belinda; Malan, Sarel F.; Castagnoli Jr., Neal; Bergh, Jacobus J.; Petzer, Jacobus P.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 3 p. 1018 - 1028
反应条件
ethanol
T=140 - 150°C;
参考文献
Lueppo-Cramer
Chemische Berichte, 1894 , vol. 27, p. 3089
反应条件
1: 2-phenyl-ethanol With sodium
T=20°C;
2: 8-Chlorocaffeine T=150°C; 6 h;
参考文献
Strydom, Belinda; Bergh, Jacobus J.; Petzer, Jacobus P.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 8 p. 3474 - 3485
