4-(6-氯哒嗪-3-基)哌嗪-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
N-ethyl-N,N-diisopropylamine in toluene T=111°C; 4 h;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 11 p. 5361 - 5379
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 0.75 h;
参考文献
XENON PHARMACEUTICALS INC.
Patent: WO2006/34440 A2, 2006 ;
Location in patent: Page/Page column 44 ;
WO 2006/034440 A2
反应条件
hydrogen; palladium 10 on activated carbon in DMF (N,N-dimethyl-formamide); ethanol
T=20°C; P=760.051 Torr;
参考文献
Di Malta, Alain; Garcia, Georges; Roux, Richard; Schoentjes, Bruno; Serradeil-Le Gal, Claudine; Tonnerre, Bernard; Wagnon, Jean
Patent: US2004/180878 A1, 2004 ;
Location in patent: Page/Page column 38 ;
