1: With trifluoroacetic acid in dichloromethane; water Inert atmosphere; 2: With sodium hydrogencarbonate in dichloromethane; water Saturated solutionInert atmosphere;

1.1: hydrogenchloride; water / toluene / 1 h / 60 °C / Inert atmosphere 1.2: 20 °C / Inert atmosphere; Saturated solution 2.1: pyridine; acetic acid / ethanol / Reflux; Inert atmosphere View Scheme