6-氟-2,3-亚甲二氧基苯甲酸甲酯合成路线 （共 3 条）
反应条件
1: 97 percent / KOH / methanol; H2O / 3 h / 20 °C
2: 93 percent / diphenoxyphosphoryl azide; Et3N / dioxane / 4.5 h / 100 °C
3: 94 percent / TFA / CH2Cl2 / 3 h / 20 °C
View Scheme
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
potassium hydroxide in methanol; water
T=20°C; 3 h;
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
1: 97 percent / KOH / methanol; H2O / 3 h / 20 °C
2: 93 percent / diphenoxyphosphoryl azide; Et3N / dioxane / 4.5 h / 100 °C
View Scheme
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
