2,5-二甲氧基-4-甲苯甲醛合成路线 （共 19 条）
反应条件
ammonium acetate in benzene
参考文献
Malesani, Giorgio; Galiano, Fabio; Ferlin, Maria Grazia; Masiero, Sergio
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 563 - 569
反应条件
1: 1.) butyllithium / 1.) THF, hexane, 20 min, 2.) THF, 30 min 2: 83 percent / 1,4-cyclohexadiene / 10 percent Pd/C / ethanol / 1 h 3: 61 percent / ceric ammonium nitrate / acetonitrile; H2O / 0.5 h View Scheme
参考文献
Hargreaves, Robert H. J.; O'Hare, C. Caroline; Hartley, John A.; Ross, David; Butler, John
Journal of Medicinal Chemistry, 1999 , vol. 42, # 12 p. 2245 - 2250
反应条件
1: ammonium acetate / 1.) reflux, 8 h, 2.) RT, 60 h 2: LiAlH4, H2SO4 / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Coutts; Malicky
Canadian Journal of Chemistry, 1974 , vol. 52, # 3 p. 395 - 399
反应条件
(i) NaBH4, iPrOH, (ii) aq. HCl; Multistep reaction;
参考文献
Nicoletti, Teresa M.; Raston, Colin L.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 1 p. 133 - 138
反应条件
nitric acid in water T=0°C; 0.666667 h;
参考文献
Malesani, Giorgio; Galiano, Fabio; Ferlin, Maria Grazia; Masiero, Sergio
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 563 - 569
反应条件
1: NH4OAc / benzene 2: LiAlH4 / tetrahydrofuran View Scheme
参考文献
Standridge; Howell; Gylys; et al.
Journal of Medicinal Chemistry, 1976 , vol. 19, # 12 p. 1400 - 1404
反应条件
1: N-methyl-N-formyl-aniline With trichlorophosphate
T=20°C; 0.833333 h; Inert atmosphere;
2: 2-methyl-1,4-dimethoxybenzene T=70°C; 1 h; Inert atmosphere;
参考文献
Miyawaki, Akari; Kikuchi, Daisuke; Niki, Masu; Manabe, Yuki; Kanematsu, Makoto; Yokoe, Hiromasa; Yoshida, Masahiro; Shishido, Kozo
Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 8231 - 8243
反应条件
trichlorophosphate in 1,2-dichloro-ethane
T=80°C; Vilsmeier-Haack formylation; 12 h;
参考文献
Mehta, Goverdhan; Khan, Tabrez Babu; Sunil Kumar
Tetrahedron Letters, 2010 , vol. 51, # 39 p. 5116 - 5119
反应条件
cobalt(III) fluoride in acetonitrile
T=20°C; Oxidation; Demethylation; 0.416667 h;
参考文献
Tomatsu, Ayumi; Takemura, Syunji; Hashimoto, Kimiko; Nakata, Masaya
Synlett, 1999 , # 9 p. 1474 - 1476
参考文献
Shulgin; Alexander T.
Patent: US4034113 A1, 1977 ;
