2,5-二甲氧基-4-甲苯甲醛合成路线 （共 19 条）
反应条件
potassium carbonate in acetone
T=25°C; 20 h;
参考文献
Ravi Kumar; Behera, Manoranjan; Raghavulu; Jaya Shree; Yennam, Satyanarayana
Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4108 - 4113
反应条件
1: 82 percent / potassium hydroxide / methanol / 8 h / steam distillation
2: 1) HCl, aluminium chloride 2) aqueous H2SO4 / 1) tetrachloroethane, 8 h, 65-70 deg C 2) overnight, room temperature 3) steam distillation
View Scheme
参考文献
Malesani, Giorgio; Galiano, Fabio; Ferlin, Maria Grazia; Masiero, Sergio
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 563 - 569
反应条件
hydrogenchloride; aluminium trichloride; sulfuric acid
1) tetrachloroethane, 8 h, 65-70 deg C 2) overnight, room temperature 3) steam distillation; Yield given. Multistep reaction;
参考文献
Malesani, Giorgio; Galiano, Fabio; Ferlin, Maria Grazia; Masiero, Sergio
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 563 - 569
参考文献
Sayigh,A.A.R. et al.
Journal of the Chemical Society, 1964 , p. 3482 - 3484
反应条件
tin(IV) chloride
1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, a) 0 deg C, 30 min, b) RT, 1 h; Yield given. Multistep reaction;
参考文献
Kretzschmann, H.; Meier, H.
Journal fuer Praktische Chemie/Chemiker-Zeitung, 1994 , vol. 336, # 3 p. 247 - 254
反应条件
1: 1.) butyllithium / 1.) THF, hexane, 20 min, 2.) THF, 30 min
2: 91 percent / 1,4-cyclohexadiene / 10 percent Pd/C / ethanol / 1 h
3: 89 percent / ceric ammonium nitrate / acetonitrile; H2O / 0.5 h
View Scheme
参考文献
Hargreaves, Robert H. J.; O'Hare, C. Caroline; Hartley, John A.; Ross, David; Butler, John
Journal of Medicinal Chemistry, 1999 , vol. 42, # 12 p. 2245 - 2250
反应条件
1: 62 percent / potasium t-butoxide / 2-methyl-propan-2-ol / 13.5 h / Heating
2: 53 percent / anhydrous sodium acetate / 4.5 h / Heating
View Scheme
参考文献
Carvalho, Christopher F.; Russo, Albert V.; Sargent, Melvyn V.
Australian Journal of Chemistry, 1985 , vol. 38, # 5 p. 777 - 792
反应条件
1: 62 percent / potasium t-butoxide / 2-methyl-propan-2-ol / 13.5 h / Heating
2: 53 percent / anhydrous sodium acetate / 4.5 h / Heating
3: 99 percent / Br2 / CCl4 / 1.) 0.5 h, reflux, 2.) 12h
View Scheme
参考文献
Carvalho, Christopher F.; Russo, Albert V.; Sargent, Melvyn V.
Australian Journal of Chemistry, 1985 , vol. 38, # 5 p. 777 - 792
反应条件
1: NH4OAc / acetic acid
2: LiAlH4 / tetrahydrofuran
View Scheme
参考文献
Standridge; Howell; Gylys; et al.
Journal of Medicinal Chemistry, 1976 , vol. 19, # 12 p. 1400 - 1404
