1,2,4-三氮唑-3-羧酸甲酯合成路线 （共 12 条）
反应条件
thionyl chloride T=10 - 20°C;
参考文献
Konstantinova; Chudinov; Fateev; Matveev; Zhurilo; Shvets; Miroshnikov
Russian Journal of Bioorganic Chemistry, 2013 , vol. 39, # 1 p. 53 - 71
Bioorganicheskaya Khimiya, 2013 , vol. 39, # 1 p. 61 - 80,20
反应条件
hydrogenchloride T=0°C; 2 h;
参考文献
Melani; Cecchi; Colotta; Catarzi; Filachioni
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 819 - 823
反应条件
1: With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate in acetonitrile T=130°C; Vorbrueggen glycosylation; 0.0833333 h; microwave irradiation; 2: With ammonia in methanol T=50°C; 16 h;
参考文献
Bookser, Brett C.; Raffaele, Nicholas B.
Journal of Organic Chemistry, 2007 , vol. 72, # 1 p. 173 - 179
反应条件
pyridine; copper diacetate in dichloromethane T=20°C; 72 h;
参考文献
US2013/158042 A1, ;
Paragraph 0219 ;
反应条件
1: 1H-[1,2,4]triazole-3-carboxylic acid methyl ester With sodium hydride in tetrahydrofuran 7 h; RefluxInert atmosphere; 2: methyl iodide in tetrahydrofuran T=20°C; Reflux;
参考文献
WO2009/147188 A1, ;
Page/Page column 101-102 ;
WO 2009/147188 A1
反应条件
ammonia in methanol T=20°C; 48 h;
参考文献
Seism, Robert A.; Stec, Donald F.; Bachmann, Brian O.
Organic Letters, 2007 , vol. 9, # 21 p. 4179 - 4182
反应条件
triethylamine in methanol; N,N-dimethyl-formamide
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2003/106459 A1, 2003 ;
Location in patent: Page 72; 108 ;
反应条件
hydrazine hydrate in methanol 24 h; Reflux;
参考文献
Bettle, Peter J.; Dawe, Louise N.; Anwar, Muhammad U.; Thompson, Laurence K.
European Journal of Inorganic Chemistry, 2011 , # 32 p. 5036 - 5042
反应条件
toluene-4-sulfonic acid in methanol
参考文献
Lee, Tai-Au; Park, Nam-Jin; Khoo, Ja-Heouk; Lee, Byung-Cheol
Patent: US2003/120064 A1, 2003 ;
反应条件
tin(IV) chloride in dichloromethane
T=5 - 20°C; 2 h; Heating / reflux;
参考文献
Clariant Life Science Molecules (Italia) SpA
Patent: EP1281715 B1, 2003 ;
Location in patent: Page/Page column 6 ;
