(2-甲基-4-喹啉)-甲醇合成路线 （共 9 条）
反应条件
N-bromosuccinmide; triphenylphosphine in tetrahydrofuran T=0 - 20°C;
参考文献
Bristol-Myers Squibb Company
Patent: US2009/18163 A1, 2009 ;
Location in patent: Page/Page column 20 ;
US 20090018163 A1
反应条件
thionyl chloride; N,N-dimethyl-formamide in dichloromethane T=20 - 30°C; 16 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/24715 A1, 2004 ;
Location in patent: Page 69 ;
WO 2004/024715 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 16.33 h;
2: With sodium hydroxide; water in tetrahydrofuran
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/6925 A1, 2004 ;
Location in patent: Page/Page column 48 ;
WO 2004/006925 A1
反应条件
ammonium sulfate; sulfuric acid in methanol; water
参考文献
Xue, Chu-Biao; Decicco, Carl P.; He, Xiaohua
Patent: US6429213 B1, 2002 ;
US 6429213 B1
反应条件
sulfuric acid; hydroxylamine-o-sulphonic acid; iron(II) sulfate in water
T=20°C; 4 h; var. cat;;
参考文献
Citterio, Attilio; Gentile, Anna; Minisci, Francesco; Serravalle, Marco; Ventura, Susanna
Tetrahedron, 1985 , vol. 41, # 3 p. 617 - 620
反应条件
lithium aluminium tetrahydride; diethyl ether
T=-15 - -12°C;
参考文献
Delaby et al.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1956 , vol. 243, p. 2082
反应条件
1.1: potassium hydroxide / water / 0.67 h / 50 °C / |Inert atmosphere; |Large scale
1.2: 5 h / 50 °C / |Inert atmosphere; |Large scale
2.1: boron trifluoride diethyl etherate / tetrahydrofuran / 15 h / 20 - 25 °C / |Inert atmosphere; |Large scale
2.2: 3 h / 20 - 38 °C / |Inert atmosphere; |Large scale
2.3: 0.5 h / 5 - 30 °C / |Inert atmosphere; |Large scale
View Scheme
参考文献
Wang, Youchu; Papamichelakis, Maria; Chew, Warren; Sellstedt, John; Noureldin, Razzak; Tadayon, Sam; Daigneault, Sylvain; Galante, Rocco J.; Sun, Jerry
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1253 - 1260
反应条件
(NH4)2S2O8; sulfuric acid; silver nitrate
Heating;
参考文献
Minisci, Francesco; Porta, Ombretta; Recupero, Francesco; Punta, Carlo; Gambarotti, Cristian; Pruna, Barbara; Pierini, Monica; Fontana, Francesca
Synlett, 2004 , # 5 p. 874 - 876
反应条件
1: With Dess-Martin periodane in dichloromethane
T=0°C; 1.5 h;
2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
INHIBOX LTD.
Patent: WO2008/142376 A1, 2008 ;
Location in patent: Page/Page column 68-69; 129-130 ;
WO 2008/142376 A1
