5-溴-2-(环丙基甲氧基)吡啶合成路线 （共 3 条）
反应条件
1: cyclopropyl carbinol With sodium hydride in tetrahydrofuran; mineral oil T=20°C; 0.333333 h; 2: 2-fluoro-5-bromo-pyridine in tetrahydrofuran; mineral oil T=20°C;
参考文献
WO2013/92616 A1, ;
Page/Page column 93; 94 ;
反应条件
1: cyclopropyl carbinol With sodium hydride in N,N-dimethyl-formamide; mineral oil T=10 - 35°C; 0.166667 h; 2: 2,5-dibromo-pyridine in N,N-dimethyl-formamide; mineral oil T=70°C; 1 h;
参考文献
US2011/263562 A1, ;
Page/Page column 71 ;
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane T=100°C; 1 h; Inert atmosphereMicrowave irradiation;
参考文献
SANOFI; SCHWINK, Lothar; BOSSART, Martin; GLOMBIK, Heiner; GOSSEL, Matthias; KADEREIT, Dieter; KLABUNDE, Thomas; MAIER, Thomas; STENGELIN, Siegfried
Patent: WO2014/56938 A1, 2014 ;
Location in patent: Page/Page column 45 ;
