5-溴-3-叔丁氧基羰基氨基-噻吩-2-羧酸合成路线 （共 2 条）
反应条件
1: tert-butyl 5-bromothiophen-3-ylcarbamate With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 3.5 h;
2: carbon dioxide in tetrahydrofuran
T=-78°C; 0.166667 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/63186 A1, 2004 ;
Location in patent: Page 36 ;
WO 2004/063186 A1
反应条件
1: With lithium hydroxide; water in tetrahydrofuran
T=20°C;
2: With hydrogenchloride in tetrahydrofuran; water
参考文献
SANOFI-AVENTIS
Patent: WO2007/93365 A2, 2007 ;
Location in patent: Page/Page column 75; 96 ;
WO 2007/093365 A2
