反应条件
1: 78 percent / imidazole / CH2Cl2 / 18 h / 20 °C
2: LiAlH4 / tetrahydrofuran / 2.5 h / 0 - 20 °C
3: 350 mg / MnO2 / CCl4 / 2 h / 20 °C
4: NaH / tetrahydrofuran / 24 h / 20 °C
5: 220 mg / tetrabutylammonium fluoride / CH2Cl2 / 1 h / 20 °C
6: 88 percent / CCl4; diisopropylethylamine; (dimethylamino)pyridine / acetonitrile / 2 h / -10 °C
View Scheme
参考文献
Simoni, Daniele; Romagnoli, Romeo; Baruchello, Riccardo; Rondanin, Riccardo; Rizzi, Michele; Pavani, Maria Giovanna; Alloatti, Domenico; Giannini, Giuseppe; Marcellini, Marcella; Riccioni, Teresa; Castorina, Massimo; Guglielmi, Mario B.; Bucci, Federica; Carminati, Paolo; Pisano, Claudio
Journal of Medicinal Chemistry, 2006 , vol. 49, # 11 p. 3143 - 3152
