1,2,5,6-四氢吡啶-3-羧酸甲酯合成路线 （共 14 条）
反应条件
in methanol
T=64 - 65°C; 95 h; Title compound not separated from byproducts;
参考文献
Clinch, K.; Marquez, C. J.; Parrott, M. J.; Ramage, R.
Tetrahedron, 1989 , vol. 45, # 1 p. 239 - 258
参考文献
Hess
Chemische Berichte, 1918 , vol. 51, p. 1014
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Freudenberg
Chemische Berichte, 1918 , vol. 51, p. 979,1675
反应条件
1: 94 percent / Et3N / methanol / 0.5 h / 60 °C
2: 97 percent / LDA / tetrahydrofuran / 0.08 h / -78 °C
View Scheme
参考文献
Jakobsen, Palle; Lundbeck, Jane M; Kristiansen, Marit; Breinholt, Jens; Demuth, Helle; Pawlas, Jan; Torres Candela, Maria P; Andersen, Birgitte; Westergaard, Niels; Lundgren, Karsten; Asano, Naoki
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 733 - 744
反应条件
1.1: 62 percent / K2CO3 / acetone / 24 h
2.1: NaBH4 / ethanol
2.2: 75 percent / ethanol / 2 h / Heating
3.1: 18 percent / Bu3SnH; AIBN / toluene / Heating
View Scheme
参考文献
Della, Ernest W.; Smith, Paul A.
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 4 p. 445 - 451
