5-溴-N-环丙基-2-噻吩甲酰胺合成路线 （共 3 条）
反应条件
1: in dichloromethane
T=0°C; 0.0833333 h;
2: With 4-methyl-morpholine; benzotriazol-1-ol in dichloromethane
T=0 - 5°C; 0.5 h;
3: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=0 - 20°C; 13 h;
参考文献
MASSACHUSETTS INSTITUTE OF TECHNOLOGY; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; GENZYME CORPORATION
Patent: WO2009/137081 A2, 2009 ;
Location in patent: Page/Page column 36; 40 ;
WO 2009/137081 A2
反应条件
1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 150 °C / Microwave irradiation
2: dichloromethane / 20 °C / Cooling with ice
View Scheme
参考文献
Skerlj, Renato T.; Bastos, Cecilia M.; Booker, Michael L.; Kramer, Martin L.; Barker, Robert H.; Celatka, Cassandra A.; O'Shea, Thomas J.; Munoz, Benito; Sidhu, Amar Bir; Cortese, Joseph F.; Wittlin, Sergio; Papastogiannidis, Petros; Angulo-Barturen, Inigo; Jimenez-Diaz, Maria Belen; Sybertz, Edmund
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 9 p. 708 - 713
反应条件
in dichloromethane
T=20°C; Cooling with ice;
参考文献
Skerlj, Renato T.; Bastos, Cecilia M.; Booker, Michael L.; Kramer, Martin L.; Barker, Robert H.; Celatka, Cassandra A.; O'Shea, Thomas J.; Munoz, Benito; Sidhu, Amar Bir; Cortese, Joseph F.; Wittlin, Sergio; Papastogiannidis, Petros; Angulo-Barturen, Inigo; Jimenez-Diaz, Maria Belen; Sybertz, Edmund
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 9 p. 708 - 713
