4-烯丙基-哌啶-1,4-二羧酸叔丁酯合成路线 （共 5 条）
反应条件
sodium carbonate in 1,4-dioxane
T=20°C; 16 h;
参考文献
Bleicher, Konrad H.; Wuethrich, Yves; De Boni, Maxime; Kolczewski, Sabine; Hoffmann, Torsten; Sleight, Andrew J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2519 - 2522
反应条件
1: ethanol; H2O / 18 h / 80 °C / 2660 Torr
2: DMAP; Et3N / 1,2-dimethoxy-ethane / 18 h / 20 °C
3: 1 N NaOH / 1,2-dimethoxy-ethane / 20 h / 20 °C
4: 5 percent aq. Na2CO3 / dioxane / 16 h / 20 °C
View Scheme
参考文献
Bleicher, Konrad H.; Wuethrich, Yves; De Boni, Maxime; Kolczewski, Sabine; Hoffmann, Torsten; Sleight, Andrew J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2519 - 2522
反应条件
1: DMAP; Et3N / 1,2-dimethoxy-ethane / 18 h / 20 °C
2: 1 N NaOH / 1,2-dimethoxy-ethane / 20 h / 20 °C
3: 5 percent aq. Na2CO3 / dioxane / 16 h / 20 °C
View Scheme
参考文献
Bleicher, Konrad H.; Wuethrich, Yves; De Boni, Maxime; Kolczewski, Sabine; Hoffmann, Torsten; Sleight, Andrew J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2519 - 2522
反应条件
1: DMAP; Et3N / 1,2-dimethoxy-ethane / 18 h / 20 °C
2: 1 N NaOH / 1,2-dimethoxy-ethane / 20 h / 20 °C
3: 5 percent aq. Na2CO3 / dioxane / 16 h / 20 °C
View Scheme
参考文献
Bleicher, Konrad H.; Wuethrich, Yves; De Boni, Maxime; Kolczewski, Sabine; Hoffmann, Torsten; Sleight, Andrew J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2519 - 2522
反应条件
1: 1 N NaOH / 1,2-dimethoxy-ethane / 20 h / 20 °C
2: 5 percent aq. Na2CO3 / dioxane / 16 h / 20 °C
View Scheme
参考文献
Bleicher, Konrad H.; Wuethrich, Yves; De Boni, Maxime; Kolczewski, Sabine; Hoffmann, Torsten; Sleight, Andrew J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2519 - 2522
