4-(氰基甲基)-1,4-哌啶二羧酸-1-(1,1-二甲基乙基)4-乙酯合成路线 （共 1 条）
反应条件
1: ethyl 1-tert-butyloxycarbonyl-4-piperidinecarboxylate With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene
T=-5°C; Inert atmosphere;
2: alpha-bromoacetonitrile in tetrahydrofuran; n-heptane; ethylbenzene
T=-5 - 20°C;
参考文献
F. HOFFMANN-LA ROCHE AG; ACKERMANN, Jean; CONTE, Aurelia; HUNZIKER, Daniel; NEIDHART, Werner; NETTEKOVEN, Matthias; SCHULZ-GASCH, Tanja; WERTHEIMER, Stanley
Patent: WO2010/130665 A1, 2010 ;
Location in patent: Page/Page column 136-137 ;
WO 2010/130665 A1
