1-Boc-4-羟基-哌啶-4-羧酸甲酯合成路线 （共 5 条）
反应条件
1: With lithium hydroxide hydrate; water in methanol T=60°C; 2 h; 2: With sodium hydrogen sulphate in methanol; water T=20°C;
参考文献
US2009/264450 A1, ;
Page/Page column 19 ;
US 20090264450 A1
反应条件
triethylamine in dichloromethane
参考文献
Burgoon, Hugh Alfred; Goodwin, Nicole Cathleen; Harrison, Bryce Alden; Healy, Jason Patrick; Liu, Ying; Mabon, Ross; Marinelli, Brett; Rawlins, David Brent; Rice, Dennis Stewart; Whitlock, Norris Andrew
Patent: US2009/264450 A1, 2009 ;
Location in patent: Page/Page column 18 ;
US 20090264450 A1
反应条件
1: With 5 palladium on charcoal; hydrogen in methanol; acetic acid
P=2585.81 Torr; 2 h;
2: With di-tert-butyl dicarbonate in methanol; acetic acid
参考文献
THE GENERAL HOSPITAL CORPORATION; ANNOVATION BIOPHARMA, LLC; RAINES, Douglas, E.; HUSAIN, Syed Shaukat; RANDLE, John, C.R.
Patent: WO2013/106717 A1, 2013 ;
Location in patent: Paragraph 00207 ;
反应条件
1.1: Na2S2O5 / water / 7 h / 25 °C
2.1: hydrogenchloride; water / acetic acid / 3 h / |Reflux
2.2: 12 h / |Reflux
3.1: 5 palladium on charcoal; hydrogen / acetic acid; methanol / 2 h / 2585.81 Torr
View Scheme
参考文献
THE GENERAL HOSPITAL CORPORATION; ANNOVATION BIOPHARMA, LLC; RAINES, Douglas, E.; HUSAIN, Syed Shaukat; RANDLE, John, C.R.
Patent: WO2013/106717 A1, 2013 ;
反应条件
1.1: hydrogenchloride; water / acetic acid / 3 h / |Reflux
1.2: 12 h / |Reflux
2.1: 5 palladium on charcoal; hydrogen / acetic acid; methanol / 2 h / 2585.81 Torr
View Scheme
参考文献
THE GENERAL HOSPITAL CORPORATION; ANNOVATION BIOPHARMA, LLC; RAINES, Douglas, E.; HUSAIN, Syed Shaukat; RANDLE, John, C.R.
Patent: WO2013/106717 A1, 2013 ;
