3-(2-氯-苯基)-6-氟-2-甲基-3H-喹唑啉-4-酮合成路线 （共 4 条）
反应条件
1.1: 90 percent / dimethylformamide / 24 h / 140 °C 2.1: 97 percent / NaIO4 / tetrahydrofuran; H2O / 1 h / 20 °C / pH 7 3.1: MgSO4 / methanol / 3 h / Heating 3.2: 69 percent / sodium triacetoxyborohydride; sodium cyanoborohydride / methanol / 18 h View Scheme
参考文献
Chenard; Welch; Blake; Butler; Reinhold; Ewing; Menniti; Pagnozzi
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1710 - 1717
反应条件
1: AcOH / Heating
2: AcOH / Heating
View Scheme
参考文献
Welch; Ewing; Huang; Menniti; Pagnozzi; Kelly; Seymour; Guanowsky; Guhan; Guinn; Critchett; Lazzaro; Ganong; DeVries; Staigers; Chenard
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 2 p. 177 - 181
反应条件
trichlorophosphate
cyclocondensation;
参考文献
Chenard; Menniti; Pagnozzi; Shenk; Ewing; Welch
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 11 p. 1203 - 1205
反应条件
acetic acid
Heating;
参考文献
Welch; Ewing; Huang; Menniti; Pagnozzi; Kelly; Seymour; Guanowsky; Guhan; Guinn; Critchett; Lazzaro; Ganong; DeVries; Staigers; Chenard
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 2 p. 177 - 181
