2,3-二氢-1H-吡咯[3,4-C]吡啶合成路线 （共 6 条）
反应条件
Ba(OH)2 in water T=120°C;
参考文献
GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; GOSSELIN, Francis; ZAK, Mark; ZHENG, Xiaozhang
Patent: WO2013/130935 A1, 2013 ;
Location in patent: Paragraph 0222 ;
参考文献
Bayer Aktiengesellschaft
Patent: US5312823 A1, 1994 ;
反应条件
1: methanol; sodium tetrahydroborate / 0.5 h / 0 - 10 °C 2: thionyl chloride / dichloromethane / 2 h / 20 °C 3: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / toluene / 20 °C / |Inert atmosphere 4: anhydrous xylene / 48 h / 150 °C / |Inert atmosphere 5: water; barium hydroxide / 120 °C View Scheme
参考文献
GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; GOSSELIN, Francis; ZAK, Mark; ZHENG, Xiaozhang
Patent: WO2013/130935 A1, 2013 ;
反应条件
1: thionyl chloride / dichloromethane / 2 h / 20 °C 2: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / toluene / 20 °C / |Inert atmosphere 3: anhydrous xylene / 48 h / 150 °C / |Inert atmosphere 4: water; barium hydroxide / 120 °C View Scheme
参考文献
GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; GOSSELIN, Francis; ZAK, Mark; ZHENG, Xiaozhang
Patent: WO2013/130935 A1, 2013 ;
反应条件
1: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / toluene / 20 °C / |Inert atmosphere 2: anhydrous xylene / 48 h / 150 °C / |Inert atmosphere 3: water; barium hydroxide / 120 °C View Scheme
参考文献
GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; GOSSELIN, Francis; ZAK, Mark; ZHENG, Xiaozhang
Patent: WO2013/130935 A1, 2013 ;
反应条件
1: anhydrous xylene / 48 h / 150 °C / |Inert atmosphere 2: water; barium hydroxide / 120 °C View Scheme
参考文献
GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; GOSSELIN, Francis; ZAK, Mark; ZHENG, Xiaozhang
Patent: WO2013/130935 A1, 2013 ;
