反应条件
1.1: triethylamine / N,N-dimethyl-formamide / 20 - 50 °C 1.2: 6 h / 100 °C 2.1: trichlorophosphate / 0.67 h / cooling with ice 2.2: 3 h / 20 °C 2.3: 0.5 h 3.1: ammonium acetate / 1 h / Reflux 4.1: ethanol; sodium tetrahydroborate / tetrahydrofuran / 1.5 h / 20 °C / cooling with ice 4.2: 1 h / pH 4 5.1: trichlorophosphate / 0.83 h / cooling with ice 5.2: 2.58 h / 50 °C 6.1: hydroxylamine hydrochloride; pyridine / tetrahydrofuran / 1 h / 50 °C 6.2: 3.5 h / 50 °C / Reflux View Scheme
参考文献
SANDOZ AG; KUMAR LUTHRA, Parven; BHUTA, Sachin; ABHINAY, Chandrakant Pise; DATTATRAYA, N., Chavan; SHASHIKANT, D., Metkar
Patent: WO2013/56842 A1, 2013 ;
