2-溴-4-氟苯酚合成路线

参考文献

Sumitomo Chemical Company, Limited
Patent: US4431822 A1, 1984 ;

参考文献

GENZYME CORPORATION; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; MAZITSCHEK, Ralph; CLARDY, Jon, C.; WIRTH, Dyann; WIEGAND, Roger; URGAONKAR, Sameer; BANIECKI, Mary, Lynn; CORTESE, Joseph; CELATKA, Cassandra; XIANG, Yibin; SKERLJ, Renato; BOURQUE, Elyse, M.j.
Patent: WO2011/53697 A1, 2011 ;
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50-00-0甲醛+

496-69-52-溴-4-氟苯酚

178546-34-43-溴-5-氟-2-羟基苯甲醛

参考文献

Infinity Discovery, Inc.
Patent: US2008/114167 A1, 2008 ;
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US 20080114167 A1

100-97-0乌洛托品+

496-69-52-溴-4-氟苯酚

178546-34-43-溴-5-氟-2-羟基苯甲醛

参考文献

ASTRAZENECA AB
Patent: US2010/331341 A1, 2010 ;
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参考文献

Liu, Jianming; Liu, Muwen; Yue, Yuanyuan; Zhang, Ningfei; Zhang, Yuanli; Zhuo, Kelei
Tetrahedron Letters, 2013 , vol. 54, # 14 p. 1802 - 1807

参考文献

Liu, Jianming; Liu, Muwen; Yue, Yuanyuan; Zhang, Ningfei; Zhang, Yuanli; Zhuo, Kelei
Tetrahedron Letters, 2013 , vol. 54, # 14 p. 1802 - 1807

496-69-52-溴-4-氟苯酚+

100-39-0溴化苄

660842-05-71-(苄氧基)-2-溴-4-氟苯

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TAISHO PHARMACEUTICAL CO., LTD
Patent: EP1528066 A1, 2005 ;
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496-69-52-溴-4-氟苯酚+

86864-60-0（2-溴乙氧基）-特丁基二甲基硅烷

811867-39-7

参考文献

Hoveyda, Hamid R.; Marsault, Eric; Gagnon, Rene; Mathieu, Axel P.; Vezina, Martin; Landry, Annick; Wang, Zhigang; Benakli, Kamel; Beaubien, Sylvie; Saint-Louis, Carl; Brassard, Martin; Pinault, Jean-Francois; Ouellet, Luc; Bhat, Shridhar; Ramaseshan, Mahesh; Peng, Xiaowen; Foucher, Laurence; Beauchemin, Sophie; Bherer, Patrick; Veber, Daniel F.; Peterson, Mark L.; Fraser, Graeme L.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 24 p. 8305 - 8320

80-41-12-氯乙基对甲苯磺酸酯+

496-69-52-溴-4-氟苯酚

922728-20-9

参考文献

PFIZER LIMITED
Patent: WO2008/135826 A2, 2008 ;
Location in patent: Page/Page column 186; 187 ;
WO 2008/135826 A2

496-69-52-溴-4-氟苯酚+

107-30-2氯甲基甲基醚

474711-11-0

参考文献

EISAI CO. LTD.
Patent: WO2003/76424 A1, 2003 ;
Location in patent: Page/Page column 214-215 ;