3-[(4-甲基苯甲酰)氨基]-4-氧代-戊酸甲酯合成路线 （共 5 条）
反应条件
sodium hydroxide; sulfuric acid in acetic anhydride
反应条件
1: (S)-NH2C(CO2H)CH2CO2Me With chloro-trimethyl-silane; triethylamine in dichloromethane
T=5 - 25°C;
2: 4-methyl-benzoyl chloride in dichloromethane
T=10 - 20°C; 16 h;
3: acetic anhydride With pyridine; 4-(N,N-dimethlyamino)pyridine
T=90°C; 2 h;
参考文献
DARA BIOSCIENCES, INC.; DELMEDICO, Mary Katherine
Patent: WO2010/141696 A1, 2010 ;
Location in patent: Page/Page column 120-121 ;
WO 2010/141696 A1
反应条件
4-(N,N-dimethlyamino)pyridine; Me3SiCl; acetic anhydride; triethylamine in pyridine; dichloromethane
参考文献
Lowe, Derek B.; Wickens, Philip L.; Ma, Xin; Zhang, Mingbao; Bullock, William H.; Coish, Philip D.G.; Mugge, Ingo A.; Stolle, Andreas; Wang, Ming; Wang, Yamin; Zhang, Chengzhi; Zhang, Hai-Jun; Zhu, Lei; Tsutsumi, Manami; Livingston, James N.
Patent: US2003/216391 A1, 2003 ;
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in acetic acid; ethyl acetate
T=81 - 89°C; 1 h;
参考文献
ONO PHARMACEUTICAL CO., LTD.
Patent: EP1741704 A1, 2007 ;
Location in patent: Page/Page column 5 ;
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine
T=90°C; 1 h;
参考文献
ONO PHARMACEUTICAL CO., LTD.
Patent: EP1354879 A1, 2003 ;
Location in patent: Page/Page column 54 ;
