pyridine; N,N-dimethyl-formamide in dichloromethane T=0°C; 90 h;
参考文献
Wright, Stephen W.; Petraitis, Joseph J.; Abelman, Matthew M.; Batt, Douglas G.; Bostrom, Lori L.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 19 p. 3071 - 3078
1: (i-Pr)2NEt / ethyl acetate / 2 h / 0 °C 2: NaOH / dimethylformamide / 5 h / 120 °C 3: NaH / dimethylformamide / Ambient temperature 4: NaOH / dimethylformamide / 5 h / 120 °C 5: NaH / dimethylformamide / Ambient temperature View Scheme
参考文献
Klunder, Janice M.; Hargrave, Karl D.; West, MaryAnn; Cullen, Ernest; Pal, Kollol; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1887 - 1897
1: (i-Pr)2NEt / ethyl acetate / 2 h / 0 °C 2: NaOH / dimethylformamide / 5 h / 120 °C 3: NaH / dimethylformamide / Ambient temperature 4: NaOH / dimethylformamide / 5 h / 120 °C 5: NaH / dimethylformamide / Ambient temperature View Scheme
参考文献
Klunder, Janice M.; Hargrave, Karl D.; West, MaryAnn; Cullen, Ernest; Pal, Kollol; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1887 - 1897
1: pyridine / dioxane; cyclohexane / Ambient temperature 2: xylene / Heating 3: NaH / various solvent(s) / Heating 4: 1.) NaH / 1.) DMSO, 2.) DMSO View Scheme
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
