3-(3,4-二甲氧基苯基)丙腈合成路线 （共 21 条）
反应条件
in N,N-dimethyl-formamide
Heating;
参考文献
Vincze, Zoltan; Biro, A. Beatrix; Csekei, Marton; Timari, Geza; Kotschy, Andras
Synthesis, 2006 , # 8 p. 1375 - 1385
反应条件
in ethanol; water
Heating / reflux;
参考文献
MERCK PATENT GMBH
Patent: WO2005/85220 A1, 2005 ;
Location in patent: Page/Page column 65-66 ;
WO 2005/085220 A1
反应条件
1: 85 percent / NH4Ac / toluene
2: 80 percent / NaBH4 / methanol
3: 91 percent / dimethylformamide / Heating
View Scheme
参考文献
Vincze, Zoltan; Biro, A. Beatrix; Csekei, Marton; Timari, Geza; Kotschy, Andras
Synthesis, 2006 , # 8 p. 1375 - 1385
反应条件
1: 80 percent / NaBH4 / methanol
2: 91 percent / dimethylformamide / Heating
View Scheme
参考文献
Vincze, Zoltan; Biro, A. Beatrix; Csekei, Marton; Timari, Geza; Kotschy, Andras
Synthesis, 2006 , # 8 p. 1375 - 1385
反应条件
1: NaI / ethanol
2: H2O; ethanol
View Scheme
参考文献
Sargent,L.J.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1754 - 1758
反应条件
1: (i) LiAlH4, Et2O, (ii) aq. H2SO4
2: SOCl2, PhNMe2 / CHCl3
3: NaI / ethanol
4: H2O; ethanol
View Scheme
参考文献
Sargent,L.J.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1754 - 1758
反应条件
1: SOCl2, PhNMe2 / CHCl3
2: NaI / ethanol
3: H2O; ethanol
View Scheme
参考文献
Sargent,L.J.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1754 - 1758
反应条件
1: sodium acetate; tetrabutylammomium bromide; tris-(o-tolyl)phosphine; 5 palladium on charcoal / N,N-dimethyl acetamide / 12 h / |Reflux
2: sodium tetrahydroborate; pyridine / methanol / 9 h / |Reflux
View Scheme
参考文献
LES LABORATOIRES SERVIER; CARRANZA, Maria Del Pilar; GARCIA ARANDA, Maria Isabel; GONZALEZ, José Lorenzo; SANCHEZ, Frédéric
Patent: US2014/128598 A1, 2014 ;
反应条件
chloroform; phosphorus pentachloride
参考文献
King; Robertson
Journal of the Chemical Society, 1931 , p. 1704,1708
反应条件
1.1: bromine; sodium acetate; acetic acid
2.1: ammonia; sodium; anhydrous iron chloride / 2 h / 20 °C
3.1: borane-THF / ethanol; tetrahydrofuran / 13 h
4.1: triethylamine / dichloromethane / 20 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / |Reflux
6.1: ethanol
7.1: sodium hydroxide / ethyl acetate
7.2: 18 h / |Reflux
View Scheme
参考文献
LES LABORATOIRES SERVIER; CARRANZA, Maria Del Pilar; GARCIA ARANDA, Maria Isabel; GONZALEZ, José Lorenzo; SANCHEZ, Frédéric
Patent: US2014/128598 A1, 2014 ;
