2-氯甲基吡啶-5-羧酸甲酯合成路线 （共 3 条）
反应条件
pyridine; thionyl chloride in dichloromethane
T=0 - 20°C; 2 h;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/242572 A1, 2004 ;
Location in patent: Page/Page column 105 ;
反应条件
N-chloro-succinimide in tetrachloromethane
Heating;
参考文献
Andre-Barres; Langlois; Gomez-Pacios
Tetrahedron Asymmetry, 1990 , vol. 1, # 9 p. 571 - 574
反应条件
1: calcium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 0 °C
2: thionyl chloride / dichloromethane / 3 h / 45 °C
View Scheme
参考文献
NOVARTIS AG; PFISTER, Keith B; SENDZIK, Martin
Patent: WO2011/26917 A1, 2011 ;
WO 2011/026917 A1
